0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Correspondence |

Multisite Randomized Trial of Deep Brain Stimulation

Kenneth Follett, MD, PhD; Frances Weaver, PhD; Matthew Stern, MD; William Marks, MD; Penelope Hogarth, MD; Katherine Holloway, MD; Jeff Bronstein, MD; John Duda, MD; Stacy Horn, DO; Eugene Lai, MD; Ali Samii, MD
Arch Neurol. 2005;62(10):1643-1644. doi:10.1001/archneur.62.10.1643-b.
Text Size: A A A
Published online

Extract

The recent article by Anderson et al1 and the accompanying editorial by Okun and Foote2 regarding pallidal vs subthalamic nucleus deep brain stimulation (DBS) for Parkinson disease underscores the need for further research to establish the long-term benefits and potential risks of these treatment approaches. The Department of Veterans Affairs Cooperative Studies Program (Washington, DC), in collaboration with the National Institute of Neurological Disorders and Stroke (Bethesda, Md) and the DBS device manufacturer Medtronic (Minneapolis, Minn), has launched a multicenter, randomized trial of bilateral DBS of the globus pallidus vs subthalamic nucleus in persons with Parkinson disease. This landmark study involving 6 Department of Veterans Affairs Parkinson’s Disease Research, Education, and Clinical Centers and their university affiliates is well under way; 232 patients are enrolled toward the final cohort of 316. All sites have recognized expertise with medical and surgical treatment of Parkinson disease, including experience with globus pallidus and subthalamic nucleus DBS implantation and microelectrode recording. An additional component of the study compares DBS with the best medical therapy.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 6

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Collections
PubMed Articles
Jobs
brightcove.createExperiences();