Controversies in Neurology |

Mild Cognitive Impairment as a Clinical Entity and Treatment Target

Ronald C. Petersen, PhD, MD; John C. Morris, MD
Arch Neurol. 2005;62(7):1160-1163. doi:10.1001/archneur.62.7.1160.
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Mild cognitive impairment (MCI) has been actively investigated for the past decade.1,2 The term was coined in the late 1980s by the New York University group to identify individuals who were not cognitively normal for age and yet did not have overt dementia, and their outcomes were described in an article examining predictors of dementia by Flicker et al3 in the early 1990s. Flicker et al characterized MCI as equivalent to a Global Deterioration Scale rating of 3 and found that a diagnostic approach combining a careful, structured interview and the appropriate neuropsychological tests can discriminate those individuals with MCI likely to experience cognitive deterioration from those with a benign prognosis.3

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Figure 1.

Flowchart for diagnosis of mild cognitive impairment (MCI) subtypes.

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Figure 2.

Scheme for combining clinical subtypes with presumed etiology. AD indicates Alzheimer disease; Depr, depression; DLB, dementia with Lewy bodies; FTD, frontotemporal dementia; MCI, mild cognitive impairment; and VaD, vascular dementia.

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