Correspondence |

Self- or Proxy-Reported Stroke and the Risk of Alzheimer Disease

K. M. Hayden, PhD; C. F. Pieper, DrPH; K. A. Welsh-Bohmer, PhD; J. C. S. Breitner, MD, MPH; M. C. Norton, PhD; R. Munger, PhD
Arch Neurol. 2004;61(6):982. doi:10.1001/archneur.61.6.982.
Text Size: A A A
Published online


Honig et al1 reported an association between stroke and subsequent onset of Alzheimer disease (AD) in the Washington Heights-Inwood Columbia Aging Project (hazard ratio, 1.83; 95% confidence interval, 1.14-2.95). Data from the Cache County Study2 may support these findings.

Among 3167 persons aged 65 years and older who did not have dementia initially and underwent follow-up for 3 years, we evaluated the incidence of AD in relation to the baseline self- or proxy-reported history of stroke. Table 1 presents odds ratios and 95% confidence intervals for AD onset with stroke. Additional models evaluate this relationship, controlling for important covariates and interaction terms considered by Honig and colleagues. Our analysis (using logistic regression) yielded an adjusted odds ratio of 2.03 for AD with self- or proxy-reported stroke controlling for age, sex, education, hypertension, diabetes, and myocardial infarction or coronary artery bypass graft. Whereas this estimate was similar to the estimate from the Washington Heights-Inwood Columbia Aging Project,1 the confidence interval for our estimate was broader (0.80-4.46). Two factors account for the difference in precision between the 2 estimates. Honig and colleagues had twice the number of stroke events (188 vs 98) and AD cases (212 vs 98) in their sample.

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Topics

Users' Guides to the Medical Literature
Clinical Resolution

Users' Guides to the Medical Literature
Clinical Scenario