The cognitive function of patients was measured by the MMSE, a 30-point test that assesses the domains of attention, orientation, calculation, memory, language, and visuospatial functioning, and with the Clinical Dementia Rating Scale sum of boxes (CDR SB).25 The CDR SB has a range of 0 to 18, representing the sum of 6 individual domains in the instrument; higher scores indicate worse dementia. Behavioral disturbances were assessed using the Cohen-Mansfield Agitation Inventory (CMAI),26 a 36-item, informant-based scale that rates behaviors observed in the past 2 weeks, and the Behavior Rating Scale for Dementia (BRSD),27 a 48-item, informant-based scale that rates behaviors that have occurred in the last month. The BRSD has been subjected to a factor analysis, with 6 factors being identified: behavioral dysregulation, depression, inertia, irritability/aggression, psychosis, and vegetative symptoms. The Alzheimer's Disease Cooperative Study Activities of Daily Living Inventory,28 which assesses both basic ADLs, such as bathing, grooming, walking, and dressing, and instrumental ADLs, such as handling mail, discussing current events, and using household appliances, was administered to measure functional impairment. The range of scores is 0 to 78, with higher score indicating better function.