Cognitive function and adverse effects were evaluated in 194 persons with AD who enrolled in a 24-month, long-term, open-label, 24-mg/d galantamine extension study. This study followed participation in either of 2 double-blind placebo-controlled multicenter galantamine trials with continuous open-label galantamine extension for a total original trial galantamine continuous exposure of 12 months. In trial 1,4 a US placebo-controlled multicenter study, 423 patients were originally randomized to receive galantamine, 24 or 32 mg/d, during the 6-month double-blind phase. Of those patients completing the 6-month double-blind phase, 240 elected to continue open galantamine treatment, 24 mg/d, for an additional 6 months. Of those subsequently completing continuous galantamine treatment after 12 months, 167 patients elected to enroll in the present long-term, open-label, 24-month extension study. Trial 2 was a 6-country international multicenter study.7 Twenty-seven US participants initially randomized to receive galantamine, 24 or 32 mg/d, during the 3-month double-blind phase, who then were randomized to receive galantamine in a subsequent 6-week washout phase and then completed an additional 7½ months of open-label galantamine therapy, elected to enroll in the present long-term, open-label, extension study. Thus, 194 US patients who received up to 36 months of continuous galantamine therapy, at least 24 mg/d, were included in this analysis. These 194 subjects included 184 white subjects, 6 black subjects, 3 Mexican American subjects, and 1 Asian subject.