0
Editorial |

The Endocrinology of Aging and the Brain

Steven W. J. Lamberts, MD, PhD
Arch Neurol. 2002;59(11):1709-1711. doi:10.1001/archneur.59.11.1709.
Text Size: A A A
Published online

Extract

THERE IS considerable variation in the effect of aging on healthy individuals, with some people exhibiting extensive alteration in physiological functions with age and others little or none. It has been suggested that it might be useful to distinguish between usual and successful patterns of aging.1 Genetic factors, lifestyle, and societal investments in a safe and healthy environment are important aspects of successful aging. Traditionally, the aging process, including the development of physical frailty and a gradual loss in cognitive function toward the end of life, has been considered to be physiological and unavoidable. In recent years, however, it has become evident that it might not be necessary to accept the grim stereotype of aging as an unalterable process of decline and loss.1 As life expectancy increases further in the coming decades, the overarching goal for the coming years should be an increase in years of healthy life with a full range of functional and mental capacity at the last stage of life. Such a compression of morbidity can in principle be achieved in part by healthy lifestyle measures, and these already seem to result in a decline in the prevalence of long-term disability in the elderly population.2

Figures in this Article

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Place holder to copy figure label and caption

During aging a decline in the activities of several hormonal systems occur. A, A decrease in growth hormone (GH) release by the pituitary gland causes a decrease in the production of insulin-like growth factor-I (IGF-I) by the liver and other organs. B, An increase in the release of gonadotropins (luteinizing hormone [LH] and follicle-stimulating hormone [FSH]) follows a decreased secretion at the gonadal level (from the ovaries, decreased estradiol [E2]; from the testicle, decreased testosterone [T]). C, The adrenocortical cells responsible for the production of dehydroepiandrosterone (DHEA) decrease in activity (adrenopause) without clinically evident changes in corticotropin (ACTH) and often a slight increase in cortisol secretion. These changes in hormone levels might be related to changes in physical and cognitive function in elderly individuals. PRL indicates prolactin; TSH, thyroid-stimulating hormone; equal sign, no change; and T4, thyroxine.

Graphic Jump Location

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 8

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Topics
PubMed Articles
Jobs
JAMAevidence.com

The Rational Clinical Examination
Make the Diagnosis: Will This Patient Fall?

The Rational Clinical Examination
Original Article: Will This Patient Fall?

brightcove.createExperiences();