We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Editorial |

Therapies for Disorders of the Neuromuscular Junction

J. Ned Pruitt II, MD; Thomas R. Swift, MD
Arch Neurol. 2002;59(5):739-742. doi:10.1001/archneur.59.5.739.
Text Size: A A A
Published online


DURING THE past 3 decades, the therapeutic options for patients with neuromuscular transmission disorders have greatly increased. However, debate continues on the best approach to both short-term and long-term management. Although therapies have decreased mortality, the clinical course continues to present problems for most patients. No mode of therapy has been proven to be clearly superior; therefore, the choice of therapy should focus on the individual patient.

Several factors determine the type of therapy that is most appropriate for a given patient. Ideally, the therapy should have minimal adverse effects, be easy to use, and be inexpensive. Therapeutic decisions in an acute setting are based on the patient's rate of disease progression, distribution of weakness, and confounding medical factors. Long-term therapeutic decisions are based on the patient's age, sex, and the presence of other diseases. The presence or absence of thymoma in patients with myasthenia gravis also influences the immediate treatment plan and long-term therapeutic regimen.

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

1 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles