From Table 3, the common manifestations of patients with SCA in this group include progressive cerebellar ataxia and dysarthria. Besides this, patients with SCA1 also frequently have swallowing difficulties and hyperreflexia, but no extrapyramidal symptoms or dementia. Most patients with SCA2 have hyporeflexia, swallowing difficulties, dementia, and amyotrophy, while few have slow saccades, ophthalmoplegia, pyramidal signs, and chorea. Furthermore, hyporeflexia and dementia might be helpful in clinical work to distinguish patients with SCA2 from others with different types of SCA. In patients with SCA3/MJD, spasticity, hyperreflexia, Babinski signs, nystagmus, and swallowing difficulties are frequent; slow saccades, ophthalmoplegia, facial and lingual fasciculation, and amyotrophy are next; but chorea, dementia, and hyporeflexia, are rare. Furthermore, spasticity, hyperreflexia, and Babinski signs might be helpful in clinical work to distinguish patients with SCA3/MJD from others with different types of SCA. In patients with untyped SCA, nystagmus and hyperreflexia are more frequent, while slow saccades, facial and lingual fasciculation, hyporeflexia, amyotrophy, chorea, and dementia are less frequent. In patients with sporadic SCA, hyperreflexia and spasticity are more frequent, while slow saccades, facial and lingual fasciculation, amyotrophy, and chorea are less frequent. In addition, we also discovered that nystagmus (P<.01), slow saccades (P<.05), and facial and lingual fasciculation (P<.05) are more frequent in patients with autosomal dominant compared with patients with sporadic SCA. In comparison with other studiess,1,2,5,14- 16 these differences reflect racial differentiation and dissimilar genetic backgrounds, and probably may also be associated with fewer cases (SCA1 and SCA2) and different disease duration in our study.