We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

White Matter Lesions and Disequilibrium in Older People I. Case-Control Comparison

Robert W. Baloh, MD; Qing Yue, MD; Tina M. Socotch, MS; Kathleen M. Jacobson
Arch Neurol. 1995;52(10):970-974. doi:10.1001/archneur.1995.00540340062013.
Text Size: A A A
Published online


Objective:  To investigate the relationship between subcortical white matter lesions identified on magnetic resonance imaging and gait and balance problems in older people.

Design:  Magnetic resonance imaging scans of the brain in 27 community-dwelling older patients (>75 years of age) who had subjective and objective abnormalities of gait and balance of unknown cause were compared with those of 27 age- and sex-matched control subjects. The T2-weighted intense lesions of the subcortical white matter were graded on a scale of 0 to 2.

Setting:  Outpatient clinic.

Results:  The patients had significantly (P<.01, X2) more severe subcortical white matter hyperintensities on magnetic resonance imaging than did the control group. Patients fell more frequently than did the control subjects and had slower motor responses and prolonged reaction times compared with the control subjects.

Conclusions:  Subcortical white matter lesions identified on magnetic resonance imaging are associated with gait and balance dysfunction in ambulatory older people. These lesions probably interfere with central processing of sensorimotor signals leading to impaired postural responses.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.