0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Serum Cortisol and Cerebrospinal Fluid β-Endorphins in Status Epilepticus Their Possible Relation to Prognosis

Vincent P. Calabrese, MD; Hans D. Gruemer, MD; Hem L. Tripathi, PhD; William Dewey, PhD; Carolyn A. Fortner, MS; Robert J. DeLorenzo, MD, PhD
Arch Neurol. 1993;50(7):689-693. doi:10.1001/archneur.1993.00540070009006.
Text Size: A A A
Published online

• Objective.  —To determine if blood cortisol and cerebrospinal fluid β-endorphin levels correlate with prognosis following status epilepticus.

Design.  —Twenty-seven adult patients with status epilepticus had blood cortisol and cerebrospinal fluid β-endorphin levels measured within 12 hours after the cessation of clinical seizures.

Setting.  —Patients with status epilepticus as well as patients with non—status epilepticus seizures came from the Comprehensive Epilepsy Program at the Medical College of Virginia, Richmond.

Patients.  —Twenty-seven patients with status epilepticus. Control patients for the cortisol study were patients who had acute seizures who did not meet the criteria for status epilepticus. The cerebrospinal fluid control subjects were patients without neurologic symptoms undergoing spinal anesthesia.

Outcome Measures.  —The clinical status of the patients 1 week after status epilepticus as well as the Glascow Outcome Score and the Glascow Coma Score 1 week after status epilepticus.

Results.  —The difference in blood cortisol levels in patients with status epilepticus with poor prognosis was significantly different from both patients with non—status epilepticus seizures (P<.001) and patients with status epilepticus with good prognosis (P<.01). Cerebrospinal fluid β-endorphin levels were elevated in patients with status epilepticus patients vs control subjects (P<.05), but no significant difference was noted between the patients with status epilepticus with good and poor prognosis.

Conclusions.  —Serum cortisol levels may provide a useful predictive indicator of prognosis in status epilepticus and cortisol level elevation may play a role in the pathophysiologic condition of status epilepticus.

Topics

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

15 Views
0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
×
brightcove.createExperiences();