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Mollaret's Meningitis:  A Variant of Recurrent Hereditary Polyserositis, Both Provoked by Metaraminol

Muhammed H. Barakat, MD, FACP; Hani T. Mustafa, MBChB; Ra'ad A. Shakir, MSc, FRCP
Arch Neurol. 1988;45(8):926-927. doi:10.1001/archneur.1988.00520320128030.
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• Mollaret's meningitis is a rare condition with a characteristic clinical and cerebrospinal fluid picture. In many ways it resembles recurrent hereditary polyserositis (familial Mediterranean fever) in its natural history, pattern of attacks, and response to colchicine. Association of the two conditions has been reported, so far, in two patients only. In our patient the symptoms of both conditions were induced by a metaraminol provocative infusion. We have previously introduced this as a specific diagnostic and confirmatory test for recurrent hereditary polyserositis. The possibility that the two conditions represent different manifestations of a single disease is therefore strengthened.


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