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Lymphomatoid Granulomatosis Manifested as a Mass in the Cerebellopontine Angle

Jonathan Hood; Edward R. Wilson, MD, PhD; C. Bruce Alexander, MD; Andrew Flint, MD; Kang-Jey Ho, MD, PhD
Arch Neurol. 1982;39(5):319-320. doi:10.1001/archneur.1982.00510170061022.
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Lymphomatoid granulomatosis, first described by Liebow et al1 in 1972, is a rare clinical entity characterized by angiocentric, angiodestructive lymphoreticular proliferation and granulomatous reaction. It initially involves primarily the lung, and in a subsequent sarcomatous stage extrapulmonary tissues are involved. We have recently encountered a case of lymphomatoid granulomatosis with nodular pulmonary infiltrates and symptoms of a rapidly growing mass in the cerebellopontine angle. Central nervous system involvement is by no means uncommon, as it occurs in at least 20% of all patients with lymphomatoid granulomatosis.1-3 In patients with rapidly developing CNS symptoms associated with nodular lung lesions, lymphomatoid granulomatosis should be considered a strong candidate in the differential diagnosis.

REPORT OF A CASE  In a 54-year-old man, malaise, restlessness, intermittent fever, and a 15-kg weight loss occurred during the year before admission. Initially, he was treated for a bacterial pneumonia because of bilateral nodular infiltrates shown on

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