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Article |

The Invasive Pituitary Adenoma A Prolactin-Producing Tumor

Per Olov Lundberg, MD; Börje Drettner, MD; Anders Hemmingsson, MD; Björn Stenkvist, MD; Leif Wide, MD
Arch Neurol. 1977;34(12):742-749. doi:10.1001/archneur.1977.00500240030005.
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• Invasive pituitary adenoma was diagnosed by means of a transnasal aspiration biopsy method in 11 patients with extensive destruction of bone in the sellar region. In most cases the initial symptoms were decrease of libido and potency or amenorrhea-galactorrhea. Later, chiasmatic compression developed in six patients, ocular motor signs in two, and epilepsy in two. Most of the patients had symptoms for many years; in two, the tumor was discovered by chance. They all had very high serum-prolactin values. The patients were treated with irradiation, and the prognosis seems to be relatively favorable.


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