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Correlation Between Regional Cerebral Blood Flow and Oxidative Metabolism In Vivo Studies in Man

Marcus E. Raichle, MD; Robert L. Grubb Jr, MD; Mokhtar H. Gado, MD; John O. Eichling, PhD; Michel M. Ter-Pogossian, PhD
Arch Neurol. 1976;33(8):523-526. doi:10.1001/archneur.1976.00500080001001.
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• To test the hypothesis that regional cerebral blood flow (rCBF) is normally regulated by regional metabolic activity, rCBF and the regional cerebral metabolic rate for oxygen (rCMRO2) were compared in selected human subjects. In normal subjects and patients with chronic, stable diseases of brain, rCBF correlated well with rCMRO2. In one individual with mild dementia, rCBF and rCMRO2 were measured before and during exercise of the hand and forearm contralateral to the hemisphere studied. Appropriate parallel changes occurred in both rCBF and rCMRO2 during hand exercise. In patients with acute diseases affecting the hemisphere studied, however, the correlation between rCBF and rCMRO2 was unpredictable.


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