We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

The Thrombotic Syndrome Associated With Carcinoma A Clinical and Neuropathologic Study

Thomas J. Reagan, MD; Haruo Okazaki, MD
Arch Neurol. 1974;31(6):390-395. doi:10.1001/archneur.1974.00490420056006.
Text Size: A A A
Published online


The clinical and pathologic findings were reviewed in 20 patients who had cancer and neurological symptoms associated with thromboembolic disease affecting multiple organs. Sixteen of the patients had nonbacterial thrombotic endocarditis. Large-vessel occlusions were present in nine patients. Microvascular occlusions and microinfarcts were present in 14 of the 16 patients with nonbacterial thrombotic endocarditis and in all four without it. The clinical picture may be either that of acute episodes of focal neurological dysfunction or that of a more slowly evolving diffuse organic brain syndrome. These clinical profiles are often superimposed. This disorder is a disseminated intravascular coagulation syndrome of which nonbacterial thrombotic endocarditis is a frequent manifestation. While nonbacterial thrombotic endocarditis may be a source of cerebral emboli in some of these patients, cerebrovascular occlusion also may evolve independently.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.