We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Development and Significance of Heterochromia of the Iris

Richard M. Gladstone, MD
Arch Neurol. 1969;21(2):184-192. doi:10.1001/archneur.1969.00480140084008.
Text Size: A A A
Published online


HETEROCHROMIA is an alteration in iris color and structure. Although usually benign, it may be the only clue to an underlying disorder. The purpose of this report is to discuss the development and significance of this finding and to emphasize the importance of recording it.

Description  Aristotle described the condition and called it heteroglaucos. The history books also record that the eastern Emperor Anastasios I was called Dicorus because his eyes were of different colors, and Plutarch states that Alexander the Great had heterochromia.1Heterochromia may take two forms: a hypopigmentation of the iris of whatever color, with iris hypoplasia; or a hyperpigmentation, with iris hyperplasia. The color change may involve one eye alone or both eyes and may be partial or complete. The uniocular type in which different parts of the same iris are of different colors is called heterochromia iridis, piebald iris, variegated iris, or iris


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.