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Inhibition of Focal Seizures A Clinical and Experimental Study

E. F. Vastola, MD; R. Homan, MD; A. Rosen, MD
Arch Neurol. 1969;20(4):430-439. doi:10.1001/archneur.1969.00480100106015.
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THERE is in the literature a number of observations suggesting that moderate hypothermia, 34 to 25 C might have a permissive or facilitatory influence on focal electrical seizures in the neocortex of mammals. Swinyard and Toman1 found that the threshold current for electroconvulsive seizures in unanesthetized rats decreased and the seizure duration increased during general hypothermia; the susceptibility to seizures induced by intraperitoneal pentylenetrazol and picrotoxin also increased during hypothermia. In a study2 of rats anesthetized with tribromoethanol or urethane, spontaneous unit activity in the sensorimotor cortex was found to increase when the temperature in that area was lowered 3 to 4 C by cooling the cortical surface. In unanesthetized rabbits,3 repetitive electrical stimulation of the lateral geniculate body was found to induce paroxysmal activity in the striate cortex which spread over the entire cortex and continued for a long time under general hypothermia below 30


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