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Article | April 1969

Fluorescent Protein Tracing in Multiple Sclerosis Brain Tissue

John F. Simpson, MD; Wallace W. Tourtellotte, MD, PhD; Emre Kokmem, MD; Julius A. Parker, MS; Hideo H. Itabashi, MD

Arch Neurol. 1969;20(4):373-377. doi:10.1001/archneur.1969.00480100049007.

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SIXTY to seventy percent of patients with multiple sclerosis (MS) have an elevated cerebrospinal fluid (CSF) immunoglobulin G (IgG) in the presence of normal serum IgG.^1,2 These results prompted Kabat et al¹ to suggest that IgG was synthesized in the brain. The results obtained by Frick and Scheid-Seydel,³ utilizing intravenous perfusion of radioactive IgG and albumin in a variety of patients, also suggested that the elevated CSF IgG in MS patients was derived from brain tissue or its coverings.

Recently we reported⁴ for the first time that a positive correlation existed between the concentration of IgG in MS brain tissue (plaques of demyelination and surrounding normal-appearing white matter) and the IgG content of the CSF. In subsequent reports^5,6 we suggested that the IgG in MS brain tissue was synthesized in the brain rather than derived from the blood because the blood-brain barrier appeared to be

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Simpson JF, Tourtellotte WW, Kokmem E, Parker JA, Itabashi HH. Fluorescent Protein Tracing in Multiple Sclerosis Brain Tissue. Arch Neurol. 1969;20(4):373-377. doi:10.1001/archneur.1969.00480100049007.

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