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Article |

Cerebral Metabolic and Circulatory Responses to Induced Convulsions in Animals

Fred Plum, MD; Jerome B. Posner, MD; Bart Troy, MD
Arch Neurol. 1968;18(1):1-13. doi:10.1001/archneur.1968.00470310015001.
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ABSTRACT

CONVULSIONS place a heavy metabolic demand upon the brain and are followed by metabolic and clinical sequelae which are incompletely understood. Although the blood pressure1,2 and cerebral blood flow3-6 are known to increase during seizures, efforts to quantify the increase in flow and to document the dynamics of the associated changes in cerebral metabolism have yielded fragmentary and sometimes conflicting results. Thus, some workers have reported that the oxygen tension of the cerebral tissue or venous blood falls during seizures,7,8 while others have noted a rise.9 Also, some workers have reported large increases in cerebral acid products during convulsions,6,10 while others have found no predictable elevation.5 Part of the explanation for these discrepancies may be that in many sets of observations the effects on the cerebral circulation of alterations in muscle metabolism and respiration were not always clearly differentiated from the direct metabolic

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January 1, 2001
Dirk Deleu, MD, PhD; Yolande Hanssens, MPharm; André Louon, MD
Arch Neurol. 2001;58(1):134-135. doi:.
January 1, 2001
Rose-Marie Marié, MD, PhD
Arch Neurol. 2001;58(1):134-135. doi:.
February 1, 2001
Anthony E. Lang, MD, FRCPC
Arch Neurol. 2001;58(2):315-316. doi:.
February 1, 2001
Niall Quinn, MD, FRCP
Arch Neurol. 2001;58(2):316-317. doi:.
February 1, 2001
Joseph Jankovic, MD; Ali H. Rajput, MD; Michael McDermott, PhD; Daniel Perl, MD
Arch Neurol. 2001;58(2):316-317. doi:.
March 1, 2001
Steven R. Brenner, MD
Arch Neurol. 2001;58(3):517. doi:.
March 1, 2001
Mary Ganguli, MD, MPH; Rajesh Pandav, MBBS
Arch Neurol. 2001;58(3):517. doi:.
March 1, 2001
Ian R. A. Mackenzie, MD; David G. Munoz, MD
Arch Neurol. 2001;58(3):517-518. doi:.
March 1, 2001
Glenda Halliday, PhD; Jillian Kril, PhD
Arch Neurol. 2001;58(3):517-518. doi:.
March 1, 2001
Ian R. A. Mackenzie, MD
Arch Neurol. 2001;58(3):519-520. doi:.
March 1, 2001
Glenda Halliday, PhD; Claire Shepherd, PhD
Arch Neurol. 2001;58(3):519-520. doi:.
March 1, 2001
Kurt A. Jellinger, MD, PhD
Arch Neurol. 2001;58(3):520-521. doi:.
March 1, 2001
Leon J. Thal, MD
Arch Neurol. 2001;58(3):520-521. doi:.
April 1, 2001
Colin P. Doherty, MB, MRCP(I); Andrew J. Cole, MD, FRCP(C)
Arch Neurol. 2001;58(4):678-680. doi:.
April 1, 2001
Fernando Cendes, MD, PhD; Frederick Andermann, MD, FRCPC; François Dubeau, MD, FRCPC
Arch Neurol. 2001;58(4):678-680. doi:.
April 1, 2001
Michael D. Freeman, PhD, DC, MPH
Arch Neurol. 2001;58(4):680-681. doi:.
April 1, 2001
Henry Berry, MD, DPsych, MRCP(Lond), FRCPC
Arch Neurol. 2001;58(4):680-681. doi:.
April 1, 2001
Susan B. Bressman, MD; Stanley Fahn; Laurie J. Ozelius, PhD; Patricia L. Kramer, PhD; Neil J. Risch
Arch Neurol. 2001;58(4):681-682. doi:.
April 1, 2001
Alexandra Dürr, MD, PhD; David Brassat, MD; Marie Vidailhet, MD; Alexis Brice, MD
Arch Neurol. 2001;58(4):681-682. doi:.
May 1, 2001
Erin D. Bigler, PhD
Arch Neurol. 2001;58(5):831-833. doi:.
May 1, 2001
Nicholas C. Fox, MRCP; Rhian Jenkins, BSc; Martin Rossor, FRCP
Arch Neurol. 2001;58(5):831-833. doi:.
May 1, 2001
Jagannadha R. Avasarala, MD, PhD
Arch Neurol. 2001;58(5):834. doi:.
May 1, 2001
Samia J. Khoury, MD; Howard L. Weiner, MD
Arch Neurol. 2001;58(5):834. doi:.
May 1, 2001
Kathy Kujawa, MD, PhD; Christopher G. Goetz, MD
Arch Neurol. 2001;58(5):835. doi:.
May 1, 2001
Rüdiger von Kummer, MD
Arch Neurol. 2001;58(5):835-837. doi:.
May 1, 2001
Joachim Röther, MD; Cornelius Weiller, MD; Jürgen R. Reichenbach, PhD; Michael Herzau, MD; Werner A. Kaiser, MD; Lars Jonetz-Mentzel, MD; Aanke Fiala, MS
Arch Neurol. 2001;58(5):835-837. doi:.
June 1, 2001
Gerson T. Lesser, MD; Leslie S. Libow, MD
Arch Neurol. 2001;58(6):1022-1023. doi:.
June 1, 2001
Benjamin Wolozin, MD,PhD; George Siegel, MD
Arch Neurol. 2001;58(6):1022-1023. doi:.
June 1, 2001
Edward L. E. M. Bollen; Allan Gaw, PhD; Brendan M. Buckley, MD
Arch Neurol. 2001;58(6):1023-1024. doi:.
June 1, 2001
Benjamin Wolozin, MD,PhD; George Siegel, MD
Arch Neurol. 2001;58(6):1023-1024. doi:.
June 1, 2001
Frédéric Macia, MD; Farid Yekhlef, MD; Guillaume Ballan, MD; Olivia Delmer, MD; François Tison, MD,PhD
Arch Neurol. 2001;58(6):1024-1026. doi:.
June 1, 2001
Eduard Kraft; Johannes Schwarz; Claudia Trenkwalder; Wolfgang H. Oertel
Arch Neurol. 2001;58(6):1024-1026. doi:.
July 1, 2001
Jose A. Obeso, MD; Maria C. Rodriguez, MD; Jorge Guridi, MD; Lazaro Alvarez, MD; Eduardo Alvarez, MD; Raul Macias, MD; Jorge L. Juncos, MD; Mahlon DeLong, MD
Arch Neurol. 2001;58(7):1165-1166. doi:.
July 1, 2001
Anthony E. Lang, MD, FRCPC
Arch Neurol. 2001;58(7):1165-1166. doi:.
July 1, 2001
Matthew F. Muldoon, MD, MPH
Arch Neurol. 2001;58(7):1166-1167. doi:.
July 1, 2001
Benjamin Wolozin, MD, PhD
Arch Neurol. 2001;58(7):1166-1167. doi:.
July 1, 2001
Jukka Peltola, MD; Kai Eriksson, MD PhD; Tapani Keränen, MD PhD
Arch Neurol. 2001;58(7):1168-1169. doi:.
July 1, 2001
Johan A. Aarli, MD
Arch Neurol. 2001;58(7):1168-1169. doi:.
July 1, 2001
Beatrice Alexandra Golomb, MD, PhD; Beth Jaworski, MS
Arch Neurol. 2001;58(7):1169-1170. doi:.
July 1, 2001
Benjamin Wolozin, MD, PhD; George Siegel, MD
Arch Neurol. 2001;58(7):1169-1170. doi:.
August 1, 2001
Leonardo Cocito, MD; Daniela Audenino, MD; Alberto Primavera, MD
Arch Neurol. 2001;58(8):1310. doi:.
August 1, 2001
Arch Neurol. 2001;58(8):1310. doi:.
August 1, 2001
Paolo Ferroli, MD; Laura Farina, MD; Angelo Franzini, MD; Clara Milanese, MD; Giovanni Broggi, MD
Arch Neurol. 2001;58(8):1311-1312. doi:.
August 1, 2001
Ichiro Nakashima, MD; Kazuo Fujihara, MD; Yasuto Itoyama, MD
Arch Neurol. 2001;58(8):1311-1312. doi:.
September 1, 2001
Kurt Jellinger, MD
Arch Neurol. 2001;58(9):1498-1499. doi:.
September 1, 2001
Howard A. Crystal, MD; Dennis Dickson, MD; Peter Davies, PhD; David Masur, PhD; Ellen Grober, PhD; Richard B. Lipton, MD
Arch Neurol. 2001;58(9):1498-1499. doi:.
September 1, 2001
Kurt Jellinger, MD
Arch Neurol. 2001;58(9):1499-1500. doi:.
September 1, 2001
Karen J. Kluin, MS; Sid Gilman, MD; Norman L. Foster, MD; Constance J. D'Amato, BS; Laurie Bluemlein, RN, MS; Roderick Little, PhD; Anders A. F. Sima, MD, PhD; Leslie A. Bruch, MD; Jewel R. Johanns, PhD
Arch Neurol. 2001;58(9):1499-1500. doi:.
October 1, 2001
Michael D. Hill, MD, FRCPC; Frank L. Silver, MD, FRCPC
Arch Neurol. 2001;58(10):1705. doi:.
October 1, 2001
Arch Neurol. 2001;58(10):1705. doi:.
October 1, 2001
Paul T. Akins, MD, PhD
Arch Neurol. 2001;58(10):1705-1706. doi:.
October 1, 2001
John C. Morris, MD; Martha Storandt, PhD; J. Phillip Miller, AB; Daniel W. McKeel, MD; Joseph L. Price, PhD; Eugene H. Rubin, MD, PhD; Leonard Berg, MD
Arch Neurol. 2001;58(10):1705-1706. doi:.
November 1, 2001
Giovanni B. Frisoni, MD; Cristina Geroldi, MD, PhD
Arch Neurol. 2001;58(11):1939-1940. doi:.
November 1, 2001
Leon J. Thal, MD
Arch Neurol. 2001;58(11):1939-1940. doi:.
March 1, 2002
Lisbeth Evered, BSc; Brendan Silbert, MB, BS, FANZCA; Paul Maruff, PhD; Alexander Collie, PhD; David Scott, MB, BS, FANZCA
Arch Neurol. 2002;59(3):489-490. doi:.
March 1, 2002
Ola A. Selnes, PhD; Richard M. Royall, PhD; Maura A. Grega, MSN; Louis M. Borowicz Jr, MS; Guy M. McKhann, MD
Arch Neurol. 2002;59(3):489-490. doi:.
May 1, 2002
Arnulf H. Koeppen, MD
Arch Neurol. 2002;59(5):874. doi:.
May 1, 2002
Paula Coutinho, MD, PhD; Clara Barbot, MD
Arch Neurol. 2002;59(5):874. doi:.
May 1, 2002
Douglas J. Lanska, MD
Arch Neurol. 2002;59(5):874-875. doi:.
May 1, 2002
Christopher G. Goetz, MD
Arch Neurol. 2002;59(5):874-875. doi:.
May 1, 2002
Rollin James Hawley, MD; William T. Hendricks, MD
Arch Neurol. 2002;59(5):875-876. doi:.
May 1, 2002
Christopher S. Williams, USAF, MC; Gustavo C. Román, MD; Elizabeth Butler, MD
Arch Neurol. 2002;59(5):875-876. doi:.
June 1, 2002
Franck Semah, MD; Catherine Lamy, MD; Sophie Demeret, MD
Arch Neurol. 2002;59(6):1042-1043. doi:.
June 1, 2002
Dennis J. Dlugos, MD
Arch Neurol. 2002;59(6):1042-1043. doi:.
June 1, 2002
David E. Riley, MD
Arch Neurol. 2002;59(6):1043. doi:.
June 1, 2002
Fernando Pompeu, MD; John H. Growdon, MD
Arch Neurol. 2002;59(6):1043. doi:.
June 1, 2002
Tetsuo Sakai, MD; Katsue Miyoshi, MD
Arch Neurol. 2002;59(6):1044-1045. doi:.
June 1, 2002
Thorsten Schulte, MD; Ludger Schöls, MD
Arch Neurol. 2002;59(6):1044-1045. doi:.
July 1, 2002
Lars-Olof Wahlund, MD, PhD; Christian Andersen, MD, MSc; Per Östberg, BSc
Arch Neurol. 2002;59(7):1203-1204. doi:.
July 1, 2002
Guy M. McKhann, MD; John Q. Trojanowski, MD, PhD; Murray Grossman, MD, EdD
Arch Neurol. 2002;59(7):1203-1204. doi:.
August 1, 2002
Michael P. Collins, MD; M. Isabel Periquet, MD
Arch Neurol. 2002;59(8):1333-1334. doi:.
August 1, 2002
Kirsten de Groot, MD; Eva Reinhold-Keller, MD
Arch Neurol. 2002;59(8):1333-1334. doi:.
August 1, 2002
Michael S. Okun, MD; Jerrold L. Vitek, MD, PhD; Mahlon R. DeLong, MD
Arch Neurol. 2002;59(8):1334-1335. doi:.
August 1, 2002
Joseph Jankovic, MD
Arch Neurol. 2002;59(8):1334-1335. doi:.
September 1, 2002
Aileen McGonigal, MRCP; Maria Oto, MRCGP; Aline J. C. Russell, MRCP; John Greene, MD, MRCP; Roderick Duncan, MD, PhD, FRCP
Arch Neurol. 2002;59(9):1491. doi:.
September 1, 2002
John R. Gates, MD
Arch Neurol. 2002;59(9):1491. doi:.
November 1, 2002
Bernd Pohlmann-Eden, MD, PhD; Michael G. Hennerici, MD, PhD; Daniel B. Hoch, MD, PhD
Arch Neurol. 2002;59(11):1831-1832. doi:.
November 1, 2002
Isaac E. Silverman, MD; Lucas Restrepo, MD; Gregory C. Mathews, MD, PhD
Arch Neurol. 2002;59(11):1831-1832. doi:.
November 1, 2002
Susan L. Perlman, MD
Arch Neurol. 2002;59(11):1832. doi:.
November 1, 2002
David R. Lynch, MD, PhD; Jennifer M. Farmer, MS; Laura J. Balcer, MD, MSCE; Robert B. Wilson, MD, PhD
Arch Neurol. 2002;59(11):1832. doi:.
December 1, 2002
Maria-Joao Ribeiro, MD, PhD; Marie Vidailhet, MD; Philippe Remy, MD, PhD
Arch Neurol. 2002;59(12):1973-1974. doi:.
December 1, 2002
Mathias Mäurer, MD; Ralf Linker, MD; Ralf Gold, MD; Klaus V. Toyka, MD; Michael Sendtner, MD; Peter Rieckmann, MD
Arch Neurol. 2002;59(12):1974-1975. doi:.
March 1, 2007
Daniel C. Payne, PhD, MSPH; Charles E. Rose Jr, PhD; John Kerrison, MD; Aaron Aranas, MBA, MPH; Susan Duderstadt, MD, MPH; Michael M. McNeil, MD, MPH
Arch Neurol. 2007;64(3):458. doi:10.1001/archneur.64.3.458-a.
March 1, 2007
Osamu I. Kano, MD; Keisuke Arasaki, MD; Ken Ikeda, MD; Yasuo Iwasaki, MD
Arch Neurol. 2007;64(3):458-459. doi:10.1001/archneur.64.3.458-b.
December 1, 2002
Hubert H. Fernandez, MD; Joseph H. Friedman, MD
Arch Neurol. 2002;59(12):1973. doi:.
December 1, 2002
Volker Hoffmann, MD; Cornelia Hardt, MD
Arch Neurol. 2002;59(12):1974. doi:.
January 1, 2004
Mario Di Napoli, MD; Arsen Arakelyan, MBiochem
Arch Neurol. 2004;61(1):155. doi:.
January 1, 2004
Kyusik Kang, MD; Kon Chu, MD; Jae-Kyu Roh, MD, PhD
Arch Neurol. 2004;61(1):155-156. doi:.
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