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Uveomeningoencephalitic Syndrome (Vogt-Koyanagi-Harada)

Arch Neurol. 1965;12(2):197-205. doi:10.1001/archneur.1965.00460260087010.
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UVEOMENINGOENCEPHALITIC syndrome (Vogt-Koyanagi-Haranda [VKH]) is an unusual syndrome with important neurological complications and has not, to my knowledge, been discussed in English in the neurological literature. VKH is a multisystem disorder and includes idiopathic uveitis, dysacousia, leukodermia, alopecia, canities (whitened hair), poliosis (whitened eyebrows and eyelashes), acute encephalitic signs, and fluctuating meningeal symptoms both central and peripheral. The syndrome has been described only in ophthalmological journals, save for a few recent dermatologic and otolaryngologic reports and papers scattered in foreign journals.

The neurological aspects of the syndrome have become appreciated only gradually, which Walsh (1957)34 has summarized in his neuroophthalmology text. Reed et al (1958)26 called attention to the problem of differentiating VKH from other acute brain disorders requiring craniotomy, particularly when the intracranial pressure was increased.

In this report the clinical features of the syndrome will be surveyed, and two cases focusing on neurological aspects will


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