0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Anatomic Changes in Congenital Insensitivity to Pain:  Absence of Small Primary Sensory Neurons in Ganglia, Roots, and Lissauer's Tract

AUGUST G. SWANSON, MD; GEORGE COLIN BUCHAN, MD; ELLSWORTH C. ALVORD JR., MD
Arch Neurol. 1965;12(1):12-18. doi:10.1001/archneur.1965.00460250016002.
Text Size: A A A
Published online

Congenital universal insensitivity or indifference to pain has been reported in about 45 cases since Dearborn's1 first description of a man with unusual tolerance for pain. The emphasis of the reports has varied, and there has been great variation in the completeness of recording of historical, neurological, and biopsy data. As recently as 1961, Kunkle2 pointed out that the available information still makes it difficult to determine whether many of the recorded cases are lacking in the ability to perceive pain "insensitivity" or have an abnormal lack of the appreciation of pain "indifference."

Biopsy of peripheral nerves has permitted identification of some cases of peripheral neuropathy,3 but in other cases no such abnormalities have been found.3,4,5 Only two detailed neuropathologic studies have been reported in cases coming to autopsy6,7; neither revealed significant abnormalities, so that one is justified in classifying these as cases of congenital

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();