Article |

Electrophysiological Alterations in Adrenalectomy:  Changes in Brain Stem Conduction, Excitability, and Sensitivity to Anesthesia in Adrenalectomized Cats

Arch Neurol. 1962;7(5):460-470. doi:10.1001/archneur.1962.04210050096011.
Text Size: A A A
Published online

Since the classical observations made by Addison on disturbances occurring in patients suffering from adrenocortical insufficiency, various neurological and mental alterations have suggested that the vital hormones are essential for normal function of the central nervous system. The mental changes in these patients consist among others of irritability, unexplained bursts of anger, disturbed sleep with nightmares, depression, periods of amnesia and unreality, and occasionally hallucinations and paranoid psychosis.1-4 Some of the patients exhibit motor and sensory disturbances, changes in reflexes, pupillary and visual abnormalities, drowsiness, and confusion, which is occasionally accompanied by convulsions.1-3 Among other abnormalities described in hypoadrenalism are slowing of the EEG in patients1,2,5,6 and experimental animals7 and an increase in brain excitability of the latter,8,9 as determined by the threshold for electrically induced seizures.

Various metabolic derangements in the central nervous system have been described in hypoadrenalism,9 but there is very


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.