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Comment & Response |

Diagnosing Traumatic Encephalopathy Syndrome ONLINE FIRST

Uzma Samadani, MD, PhD1; Molly Hubbard, MD1
[+] Author Affiliations
1Neurosurgery, Hennepin County Medical Center, Minneapolis, Minnesota
JAMA Neurol. Published online September 19, 2016. doi:10.1001/jamaneurol.2016.2802
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To the Editor We agree with Reams and colleagues’ review1 finding that because mislocalized phosphorylated tau is neither pathognomic nor causative for clinical neurodegenerative disease, efforts focusing on identification of chronic traumatic encephalopathy in living people are not clinically useful. Chronic traumatic encephalopathy is present in equal incidence in normal healthy elderly individuals as in people with neurodegenerative disease.2 It is a pathologic finding with no clinical correlate.3,4


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September 19, 2016
Nicole Reams, MD; Matthew L. Lorincz, MD, PhD; Jeffrey S. Kutcher, MD
1Department of Neurology, NorthShore University Health System, Glenview, Illinois
2Department of Neurology, University of Michigan, Ann Arbor
3The Sports Neurology Clinic at the CORE Institute, Brighton, Michigan
JAMA Neurol. Published online September 19, 2016.;():. doi:10.1001/jamaneurol.2016.3423.
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