0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Original Investigation |

Endovascular Therapy for Acute Ischemic Stroke With Occlusion of the Middle Cerebral Artery M2 Segment ONLINE FIRST

Amrou Sarraj, MD1; Navdeep Sangha, MD2; Muhammad Shazam Hussain, MD3; Dolora Wisco, MD3; Nirav Vora, MD4; Lucas Elijovich, MD5; Nitin Goyal, MD5; Michael Abraham, MD6; Manoj Mittal, MD6; Lei Feng, MD2; Abel Wu, MD2; Vallabh Janardhan, MD7; Suman Nalluri, MD7; Albert J. Yoo, MD7; Megan George, MD8; Randall Edgell, MD9; Rutvij J. Shah, MD1; Clark Sitton, MD1; Emilio Supsupin, MD1; Suhas Bajgur, MD1; M. Carter Denny, MD1; Peng R. Chen, MD10; Mark Dannenbaum, MD10; Sheryl Martin-Schild, MD11; Sean I. Savitz, MD1; Rishi Gupta, MD8
[+] Author Affiliations
1University of Texas at Houston Stroke Center, University of Texas Health Foundation, University of Texas Health Science Center, Houston
2Department of Neurology, Kaiser Permanente, Los Angeles, California
3Department of Neurology, Cleveland Clinic Health Foundation, Cleveland, Ohio
4Department of Neurology, Ohio Health Methodist Riverside Hospital, Columbus
5Department of Neurology, University of Tennessee, Memphis
6Department of Neurology, University of Kansas Medical Center, Kansas City
7Department of Neurology, Texas Stroke Institute, Plano
8Department of Neurology, WellStar Hospital, Marietta, Georgia
9Department of Neurology, Saint Louis University Hospital, Saint Louis, Missouri
10Department of Neurosurgery, University of Texas Health Science Center, Houston
11Department of Neurology, Tulane University, New Orleans, Louisiana
JAMA Neurol. Published online September 12, 2016. doi:10.1001/jamaneurol.2016.2773
Text Size: A A A
Published online

Importance  Randomized clinical trials have shown the superiority of endovascular therapy (EVT) compared with best medical management for acute ischemic strokes with large vessel occlusion (LVO) in the anterior circulation. However, of 1287 patients enrolled in 5 trials, 94 with isolated second (M2) segment occlusions were randomized and 51 of these received EVT, thereby limiting evidence for treating isolated M2 segment occlusions as reflected in American Heart Association guidelines.

Objective  To evaluate EVT safety and effectiveness in M2 occlusions in a cohort of patients with acute ischemic stroke.

Design, Setting, and Participants  This multicenter retrospective cohort study pooled patients with acute ischemic strokes and LVO isolated to M2 segments from 10 US centers. Patients with acute ischemic strokes and LVO in M2 segments presenting within 8 hours from their last known normal clinical status (LKN) from January 1, 2012, to April 30, 2015, were divided based on their treatment into EVT and medical management groups. Logistic regression was used to compare the 2 groups. Univariate and multivariate analyses evaluated associations with good outcome in the EVT group.

Main Outcomes and Measures  The primary outcome was the 90-day modified Rankin Scale score (range, 0-6; scores of 0-2 indicate a good outcome); the secondary outcome was symptomatic intracerebral hemorrhage.

Results  A total of 522 patients (256 men [49%]; 266 women [51%]; mean [SD] age, 68 [14.3] years) were identified, of whom 288 received EVT and 234 received best medical management. Patients in the medical management group were older (median [interquartile range] age, 73 [60-81] vs 68 [56-78] years) and had higher rates of intravenous tissue plasminogen activator treatment (174 [74.4%] vs 172 [59.7%]); otherwise the 2 groups were balanced. The rate of good outcomes was higher for EVT (181 [62.8%]) than for medical management (83 [35.4%]). The EVT group had 3 times the odds of a good outcome as the medical management group (odds ratio [OR], 3.1; 95% CI, 2.1-4.4; P < .001) even after adjustment for age, National Institute of Health Stroke Scale (NIHSS) score, Alberta Stroke Program Early Computed Tomographic Score (ASPECTS), intravenous tissue plasminogen activator treatment, and time from LKN to arrival in the emergency department (OR, 3.2; 95% CI, 2-5.2; P < .001). No statistical difference in symptomatic intracerebral hemorrhage was found (5.6% vs 2.1% for the EVT group vs the medical management group; P = .10). The treatment effect did not change after adjusting for center (OR, 3.3; 95% CI, 1.9-5.8; P < .001). Age, NIHSS score, ASPECTS, time from LKN to reperfusion, and successful reperfusion score of at least 2b (range, 0 [no perfusion] to 3 [full perfusion with filling of all distal branches]) were independently associated with good outcome of EVT. A linear association was found between good outcome and time from LKN to reperfusion.

Conclusions and Relevance  Although a randomized clinical trial is needed to confirm these findings, available data suggest that EVT is reasonable, safe, and effective for LVO of the M2 segment relative to best medical management.

Figures in this Article

Figures

Place holder to copy figure label and caption
Figure 1.
Modified Rankin Scale Scores at 90 Days

Outcomes are compared for the endovascular therapy (EVT) vs medical management groups.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.
Clinical Outcomes of Patients in the Endovascular Therapy Group Related to Time

Clinical outcomes of 288 patients in the endovascular therapy group are given as modified Rankin Scale scores (range, 0-6, with lower scores indicating better outcomes) at 90 days stratified by time from the last known normal clinical status (LKN) to recanalization.

Graphic Jump Location

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

937 Views
0 Citations
×

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Collections
PubMed Articles
Jobs
brightcove.createExperiences();