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Comment & Response |

Association Between Rosacea and Parkinson Disease

Athanasia Alexoudi, MD, MsC, PhD1; Iliana Alexoudi, MD2; Stylianos Gatzonis, MD, PhD1
[+] Author Affiliations
1Department of Neurosurgery, University of Athens Medical School, Evangelismos Hospital, Athens, Greece
2Department of Dermatology, Royal Free Hospital, London, England
JAMA Neurol. 2016;73(9):1159. doi:10.1001/jamaneurol.2016.2321.
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To the Editor We considered very interesting the article by Egeberg et al1 in JAMA Neurology demonstrating that rosacea constitutes an independent risk factor for Parkinson disease (PD). Clinically, rosacea is characterized by the features of neurogenic inflammation. The participation of the sensory and/or autonomic nervous system in the pathogenesis of the disease has been confirmed with the use of immunohistochemistry techniques.2 Interestingly, dysregulation of mediators and receptors implicated in neurovascular and neuroimmune communication has been proven to be present even at early stages of rosacea.


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September 1, 2016
Alice He, BS; Ronald J. Sweren, MD; Shawn G. Kwatra, MD
1Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland
JAMA Neurol. 2016;73(9):1158-1159. doi:10.1001/jamaneurol.2016.1875.
September 1, 2016
Alexander Egeberg, MD, PhD; Jacob P. Thyssen, MD, PhD, DMSci
1Department of Dermatology and Allergy, Herlev and Gentofte University Hospital, University of Copenhagen, Hellerup, Denmark
JAMA Neurol. 2016;73(9):1159-1160. doi:10.1001/jamaneurol.2016.1864.
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