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Comment & Response |

Use of Diffusion-Weighted Magnetic Resonance Imaging in Sporadic Creutzfeldt-Jakob Disease—Reply

Laura Eisenmenger, MD1; Simon Mead, PhD2; Harpreet Hyare, PhD2
[+] Author Affiliations
1Department of Radiology, University of Utah, Salt Lake City
2MRC Prion Unit, Department of Neurodegenerative Diseases, UCL Institute of Neurology, London, England
JAMA Neurol. 2016;73(9):1154. doi:10.1001/jamaneurol.2016.2384.
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In Reply We thank Vitali and colleagues for their correspondence. We studied serial diffusion-weighted brain magnetic resonance imaging in sporadic Creutzfeldt-Jakob disease using a visual rating method.1 The rarity and very rapid clinical declines seen in this disease make serial imaging studies of a large patient sample at a single institution challenging. There is an unmet need for imaging biomarkers of progression that might be practical for use in a study that necessitates different scanners across a large region, thereby closer to the patient’s home. Our main finding was an increase in diffusion-weighted signal intensity in 59 of 62 brain regions, with the most marked changes being seen in the caudate and putamen.1 We went on to study histopathological correlates of signal change in a single brain region, the left frontal cortex.


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September 1, 2016
Paolo Vitali, MD, PhD; Marina Pan, MD; Eduardo Caverzasi, MD
1Neuroradiology and Brain MRI 3T Mondino Research Center, C. Mondino National Neurological Institute, Pavia, Italy
2Department of Neurology, University of California–San Francisco3Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy
JAMA Neurol. 2016;73(9):1153-1154. doi:10.1001/jamaneurol.2016.2381.
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