Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Editorial |

The Puzzle of Huntington Disease Phenocopies

Nicolas Dupré, MD, MSc, FCRP(C)1,2; Guy Rouleau, MD, PhD, FRCP(C)3
[+] Author Affiliations
1Faculty of Medicine, Laval University, Quebec City, Quebec, Canada
2Clinic of Neuromuscular and Neurogenetic Diseases, Centre Hospitalier Universitaire de Québec-Université Laval, Quebec City, Quebec, Canada
3Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
JAMA Neurol. 2016;73(9):1056-1058. doi:10.1001/jamaneurol.2016.2095.
Text Size: A A A
Published online


Huntington disease (HD) is a progressive disorder causing motor, cognitive, and psychiatric disturbances, with a mean age at onset of 35 to 44 years and a median survival time of 15 to 18 years.1 Although most cases have the classic triplet repeat expansion, HD specialists all follow up patients who have all the cardinal features of HD but do not have the HD mutation. These cases are problematic because genetic counseling is difficult, the prognosis is uncertain, and the fear is that a potentially treatable condition may be missed.

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Collections