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Comment & Response |

Computed Tomography Perfusion and Diffusion-Weighted Imaging in Patients With Acute Stroke—Reply

Salvatore Rudilosso, MD1; Xabier Urra, MD, PhD1,2; Ángel Chamorro, MD, PhD1,2,3
[+] Author Affiliations
1Functional Unit of Cerebrovascular Diseases, Hospital Clínic, Barcelona, Spain
2Institut d’Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
3Department of Medicine, School of Medicine, University of Barcelona, Barcelona, Spain
JAMA Neurol. 2016;73(8):1032-1033. doi:10.1001/jamaneurol.2016.1683.
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In Reply We thank Luo and colleagues for their interest and comments regarding our article on patients presenting lacunar syndrome with altered brain computed tomography perfusion (CTP) and normal magnetic resonance imaging (MRI) findings.1

They are correct that CTP and MRI were not done simultaneously in the 2 patients, which would have added interesting information on the time course of development of those lesions. We also agree that cytotoxic edema visible on MRI may require some time to develop and that the hypoperfusion seen in CTP must, therefore, exist before the MRI captures the lesion. Consequently, clinical fluctuations may be the result of the progression of the ischemic process leading to a positive follow-up MRI finding.


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August 1, 2016
Yun Luo, MD; Peng-Peng Niu, MD; Yi Yang, MD, PhD
1Stroke Center, Department of Neurology, First Hospital of Jilin University, Chang Chun, China
JAMA Neurol. 2016;73(8):1032. doi:10.1001/jamaneurol.2016.1680.
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