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Comment & Response |

Proton Pump Inhibitors and Dementia Incidence—Reply

Willy Gomm, PhD1; Britta Haenisch, PhD1
[+] Author Affiliations
1German Center for Neurodegenerative Diseases, Bonn, Germany
JAMA Neurol. 2016;73(8):1028-1029. doi:10.1001/jamaneurol.2016.1494.
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In Reply First, we thank the authors of the letters for their interest and comments concerning our article.1

Keller raises the issue that aluminum-containing antacids may have contributed to the onset of dementia. While the involvement of aluminum in the etiology of dementia still seems to be a matter of debate,2,3 this issue is interesting to examine in further studies. For our analysis, we were not able to include aluminum-containing antacids as these drugs are often not covered by the statutory health insurance in Germany. In a previous primary data analysis by our group, aluminum-containing antacids did not affect the results of proton pump inhibitor (PPI) exposure and dementia risk; however, this aspect was not included in the final publication.4

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August 1, 2016
David Louis Keller, MD
1Lomita, California
JAMA Neurol. 2016;73(8):1025. doi:10.1001/jamaneurol.2016.1488.
August 1, 2016
Tomoyuki Kawada, MD
1Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
JAMA Neurol. 2016;73(8):1025-1026. doi:10.1001/jamaneurol.2016.1491.
August 1, 2016
Helge L. Waldum, MD, PhD; Tom Christian Martinsen, MD, PhD
1Norwegian University of Science and Technology2Department of Gastroenterology and Liver Diseases, St Olavs Hospital, Trondheim, Norway
JAMA Neurol. 2016;73(8):1026. doi:10.1001/jamaneurol.2016.1497.
August 1, 2016
Jineane V. Venci, PharmD, BCACP; Katherine W. Eisenberg, MD, PhD
1University of Rochester Medical Center, Rochester, New York
JAMA Neurol. 2016;73(8):1026. doi:10.1001/jamaneurol.2016.1500.
August 1, 2016
William D. Freeman, MD
1Department of Critical Care, Mayo Clinic, Jacksonville, Florida2Department of Neurosurgery, Mayo Clinic, Jacksonville, Florida3Department of Neurology, Mayo Clinic, Jacksonville, Florida
JAMA Neurol. 2016;73(8):1026-1027. doi:10.1001/jamaneurol.2016.1503.
August 1, 2016
Kanika Sharma, MD; Alireza Minagar, MD; Hai Sun, MD, PhD
1Department of Neurosurgery, Louisiana State University Health Sciences Center, Shreveport
2Department of Neurology, Louisiana State University Health Sciences Center, Shreveport
JAMA Neurol. 2016;73(8):1027. doi:10.1001/jamaneurol.2016.1959.
August 1, 2016
Long Nguyen, MD, MS; Chin Hur, MD, MPH
1Gastroenterology, Massachusetts General Hospital, Boston
JAMA Neurol. 2016;73(8):1027-1028. doi:10.1001/jamaneurol.2016.1962.
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