We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Comment & Response |

Proton Pump Inhibitors and Dementia Incidence—Reply

Willy Gomm, PhD1; Britta Haenisch, PhD1
[+] Author Affiliations
1German Center for Neurodegenerative Diseases, Bonn, Germany
JAMA Neurol. 2016;73(8):1028-1029. doi:10.1001/jamaneurol.2016.1494.
Text Size: A A A
Published online


In Reply First, we thank the authors of the letters for their interest and comments concerning our article.1

Keller raises the issue that aluminum-containing antacids may have contributed to the onset of dementia. While the involvement of aluminum in the etiology of dementia still seems to be a matter of debate,2,3 this issue is interesting to examine in further studies. For our analysis, we were not able to include aluminum-containing antacids as these drugs are often not covered by the statutory health insurance in Germany. In a previous primary data analysis by our group, aluminum-containing antacids did not affect the results of proton pump inhibitor (PPI) exposure and dementia risk; however, this aspect was not included in the final publication.4


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





August 1, 2016
David Louis Keller, MD
1Lomita, California
JAMA Neurol. 2016;73(8):1025. doi:10.1001/jamaneurol.2016.1488.
August 1, 2016
Tomoyuki Kawada, MD
1Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
JAMA Neurol. 2016;73(8):1025-1026. doi:10.1001/jamaneurol.2016.1491.
August 1, 2016
Helge L. Waldum, MD, PhD; Tom Christian Martinsen, MD, PhD
1Norwegian University of Science and Technology2Department of Gastroenterology and Liver Diseases, St Olavs Hospital, Trondheim, Norway
JAMA Neurol. 2016;73(8):1026. doi:10.1001/jamaneurol.2016.1497.
August 1, 2016
Jineane V. Venci, PharmD, BCACP; Katherine W. Eisenberg, MD, PhD
1University of Rochester Medical Center, Rochester, New York
JAMA Neurol. 2016;73(8):1026. doi:10.1001/jamaneurol.2016.1500.
August 1, 2016
William D. Freeman, MD
1Department of Critical Care, Mayo Clinic, Jacksonville, Florida2Department of Neurosurgery, Mayo Clinic, Jacksonville, Florida3Department of Neurology, Mayo Clinic, Jacksonville, Florida
JAMA Neurol. 2016;73(8):1026-1027. doi:10.1001/jamaneurol.2016.1503.
August 1, 2016
Kanika Sharma, MD; Alireza Minagar, MD; Hai Sun, MD, PhD
1Department of Neurosurgery, Louisiana State University Health Sciences Center, Shreveport
2Department of Neurology, Louisiana State University Health Sciences Center, Shreveport
JAMA Neurol. 2016;73(8):1027. doi:10.1001/jamaneurol.2016.1959.
August 1, 2016
Long Nguyen, MD, MS; Chin Hur, MD, MPH
1Gastroenterology, Massachusetts General Hospital, Boston
JAMA Neurol. 2016;73(8):1027-1028. doi:10.1001/jamaneurol.2016.1962.
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...