0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
In This Issue of JAMA Neurology |

Highlights FREE

JAMA Neurol. 2016;73(4):369. doi:10.1001/jamaneurol.2015.2449.
Text Size: A A A
Published online

RESEARCH

Sillanpää and coauthors determine whether progress has been made in the prevention of epilepsy in Finland during the last 40 years. Using a long-term national register study of 5.04 million Finnish individuals, they looked at first-time inpatient admissions in Finland for a diagnosis of epilepsy from 1973 to 2013. They report no evidence that progress has been made in preventing new-onset epilepsy in those younger than 65 years in the last 40 years; in fact, there was a nearly 5-fold rise of new-onset epilepsy among the elderly population. Editorial perspective is provided by Mark Agostini, MD.

Armangué and colleagues report the clinical and immunological features of idiopathic opsoclonus-myoclonus syndrome (I-OMS) and paraneoplastic OMS (P-OMS), the occurrence of antibodies to cell surface antigens, and the discovery of a novel cell surface epitope. Retrospective cohort study and laboratory investigations of 114 adult patients with OMS at a center for autoimmune neurological disorders were done between January 2013 and September 2015. Patients with I-OMS responded better to treatment and had fewer relapses than those with P-OMS. Editorial perspective is provided by Jérôme Honnorat, MD, PhD.

Aguirre-Acevedo et al evaluate the onset and rate of cognitive decline during preclinical autosomal dominant Alzheimer disease (ADAD) and the effect of socioeconomic, vascular, and genetic factors on the cognitive decline. They performed a retrospective cohort study from January 1, 1995, through June 31, 2012, of individuals from Antioquia, Colombia, who tested positive for the ADAD-associated PSEN1 E280A mutation. Preclinical cognitive decline was evident in PSEN1 E280A mutation carriers 12 years before the onset of clinical impairment. Editorial perspective is provided by Diane B. Howieson, PhD, ABPP-CN.

CLINICAL REVIEW & EDUCATION

Jones and Cascino review the evidence for the use of neuroimaging studies in the selection of patients with drug-resistant temporal lobe epilepsy for focal cortical resection and discuss the prognostic importance of selected techniques. Randomized clinical trials, meta-analyses, and clinical retrospective case studies (≥20 patients with ≥1 year of follow-up) were identified. There is strong evidence that preoperative magnetic resonance imaging (MRI)–identified hippocampal atrophy consistent with mesial temporal sclerosis concordant with the seizure origin in the temporal lobe is a significant factor associated with a favorable outcome. Positron emission tomography studies may be valuable in individuals with unremarkable MRI findings.

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

1,204 Views
0 Citations
×

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs