0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Viewpoint | Next Generation Neurology

The Human Alzheimer Disease Project Answering the Call

Steven T. DeKosky, MD1; John H. Growdon, MD2
[+] Author Affiliations
1Department of Neurology, University of Florida College of Medicine, Gainesville
2Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
JAMA Neurol. 2016;73(4):373-374. doi:10.1001/jamaneurol.2015.4512.
Text Size: A A A
Published online

Extract

This Viewpoint outlines the roles and interactions of organizations conducting research leadsing to effective treatments for Alzheimer disease.

The epidemic of Alzheimer disease (AD) and related dementias that Katzman predicted in 19761 has come to pass, and unless something dramatic is done, it is likely to grow to alarming proportions in the future. In their editorial “The Human Alzheimer Disease Project: A New Call to Arms,”2 Rosenberg and Petersen threw down the gauntlet and challenged the medical and scientific communities, as well as the public at large, to meet this threat. They made the case that deciphering the causes and delivering effective treatment would require increasing the federal budget to $2 billion to support a focused attack on Alzheimer and related dementias. Just as Katzman’s prediction has come true, it is time for the Rosenberg and Petersen call to be fulfilled as well. President Obama’s announcement of an additional $300 million for AD research is a step in the right direction, but much larger amounts are needed to enable research leading to effective treatments for Alzheimer and related dementias.

Figures in this Article

First Page Preview

View Large
First page PDF preview

Figures

Place holder to copy figure label and caption
Figure.
An Integrated Approach for Translating Research Discoveries Into Treatments for Alzheimer Disease

The $2 billion Congressional appropriation would be channeled through the National Institutes of Health to an independent Human Alzheimer Project under the aegis of the National Institute on Aging. The double-headed arrows indicate reciprocal interactions between each entity. Pharmaceutical companies are the final pathway to drug production, but the translation of discoveries into therapies for Alzheimer disease will involve many partners.

Graphic Jump Location

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

1,067 Views
0 Citations
×

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
Jobs
JAMAevidence.com

The Rational Clinical Examination: Evidence-Based Clinical Diagnosis
Falls, Older Adults

The Rational Clinical Examination: Evidence-Based Clinical Diagnosis
Quick Reference

brightcove.createExperiences();