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Comment & Response |

25-Hydroxyvitamin D in Patients With Cognitive Decline

Marijn M. Speeckaert, MD, PhD1; Joris R. Delanghe, MD, PhD2
[+] Author Affiliations
1Department of Nephrology, Ghent University Hospital, Ghent, Belgium
2Department of Clinical Chemistry, Ghent University Hospital, Ghent, Belgium
JAMA Neurol. 2016;73(3):356-357. doi:10.1001/jamaneurol.2015.4182.
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To the Editor We read with interest the article by Miller et al.1 In a general population, it was demonstrated for the first time that vitamin D insufficiency, which was more frequently observed in African American and Hispanic individuals, was associated with significantly faster declines in both episodic memory and executive function performance. We agree with the authors that a lower vitamin D status may be associated with an increased risk for developing Alzheimer disease and dementia, as confirmed by a recent meta-analysis.2 However, measurement of the bioavailable 25-hydroxyvitamin D fraction may be a more reliable cross-racial marker of the vitamin D status compared with the total 25-hydroxyvitamin D levels.3 Because African American and Hispanic individuals have frequently lower total 25-hydroxyvitamin D levels, they are consistently classified as being vitamin D deficient.4

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March 1, 2016
Sevilay Muratli, MD; Ozlem Soyluk, MD; Fatih Tufan
1Division of Geriatrics, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
2Department of Gerontology, Faculty of Medical Sciences, Istanbul University, Istanbul, Turkey
JAMA Neurol. 2016;73(3):357. doi:10.1001/jamaneurol.2015.4188.
March 1, 2016
Joshua W. Miller, PhD; Ralph Green, MD, PhD; Charles DeCarli, MD
1Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey2Department of Medical Pathology and Laboratory Medicine, University of California, Davis
2Department of Medical Pathology and Laboratory Medicine, University of California, Davis
3Department of Neurology, University of California, Davis
JAMA Neurol. 2016;73(3):358. doi:10.1001/jamaneurol.2015.4185.
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