0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Comment & Response |

Insulin Resistance and APOE ε4

Auriel A. Willette, PhD1; Christine M. Burns, PhD2; Barbara B. Bendlin, PhD3
[+] Author Affiliations
1Iowa State University, Ames
2US Department of Veterans Affairs, Albuquerque, New Mexico
3University of Wisconsin–Madison
JAMA Neurol. 2015;72(12):1536-1537. doi:10.1001/jamaneurol.2015.3285.
Text Size: A A A
Published online

Extract

To the Editor We are writing in regard to our article published in JAMA Neurology,1 which reported on the relationship between higher insulin resistance and lower cerebral glucose uptake among late middle-aged adults as observed on fludeoxyglucose F 18–labeled positron emission tomography. In addition to main effects of insulin resistance, the study examined the effect of APOE ε4 genotype as well as tested for possible interactions between insulin resistance and APOE ε4. While the study did not find a significant interaction, the report erroneously indicated that the lack of interaction with APOE ε4 was in contrast to an earlier study by Burns et al.2 In fact, the 2 sets of findings are similar, as Burns et al,2 who studied elevated fasting plasma glucose, also did not find an interaction with APOE ε4 genotype.

Topics

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

September 1, 2015
Auriel A. Willette, PhD; Barbara B. Bendlin, PhD; Erika J. Starks, BS; Alex C. Birdsill, PhD; Sterling C. Johnson, PhD; Bradley T. Christian, PhD; Ozioma C. Okonkwo, PhD; Asenath La Rue, PhD; Bruce P. Hermann, PhD; Rebecca L. Koscik, PhD; Erin M. Jonaitis, PhD; Mark A. Sager, MD; Sanjay Asthana, MD
1Department of Food Science and Human Nutrition, Iowa State University, Ames2Neuroscience Interdepartmental Program, Iowa State University, Ames
3Clinical Science Center, Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison4Wisconsin Alzheimer’s Institute, University of Wisconsin School of Medicine and Public Health, Madison
3Clinical Science Center, Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison
3Clinical Science Center, Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison4Wisconsin Alzheimer’s Institute, University of Wisconsin School of Medicine and Public Health, Madison5Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin
6Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison
4Wisconsin Alzheimer’s Institute, University of Wisconsin School of Medicine and Public Health, Madison
3Clinical Science Center, Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison5Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin
JAMA Neurol. 2015;72(9):1013-1020. doi:10.1001/jamaneurol.2015.0613.
CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

235 Views
0 Citations
×

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Jobs
brightcove.createExperiences();