This case report describes a woman in her 60s who presented with progressive anomia with loss of word knowledge, prosopagnosia, and surface dyslexia.
Semantic variant primary progressive aphasia (svPPA) most often is due to TAR DNA-binding protein 43 (TDP-43) pathology.1 Herein, we report a case of svPPA due to a globular glial tauopathy (GGT).
Article InformationCorresponding Author: Bradley F. Boeve, MD, Mayo Clinic, 200 1st St SW, Rochester, MN 55905 (email@example.com).
Published Online: November 16, 2015. doi:10.1001/jamaneurol.2015.2711.
Study concept and design: Graff-Radford, Josephs, Parisi, Boeve.
Acquisition, analysis, or interpretation of data: Graff-Radford, Parisi, Dickson, Giannini, Boeve.
Drafting of the manuscript: Graff-Radford.
Critical revision of the manuscript for important intellectual content: All authors.
Administrative, technical, or material support: Parisi, Giannini, Boeve.
Study supervision: Josephs, Parisi, Giannini, Boeve.
Conflict of Interest Disclosures: None reported.
Funding/Support: This study was funded by grant P50 AG16574 from the National Institutes of Health.
Role of the Funder/Sponsor: The National Institutes of Health had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.