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Research Letter |

Genetic Correlation Between Schizophrenia and Epilepsy

Frederick W. Vonberg, MA, MBBS1,2; Tim B. Bigdeli, PhD3
[+] Author Affiliations
1Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, England
2currently with Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts
3Virginia Commonwealth University, Richmond
JAMA Neurol. 2016;73(1):125-126. doi:10.1001/jamaneurol.2015.3480.
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This retrospective case-control analysis used a technique called linkage disequilibrium score regression to estimate the genetic correlation between schizophrenia and epilepsy.

Neuropathological, clinical, and epidemiological data suggest that schizophrenia and epilepsy are associated.1 Reported estimates of the prevalence of schizophrenia among people with epilepsy vary, depending on phenotypic definition, but may be around 7%.2 One hypothesis to account for the relationship is that the 2 diseases share a common etiology. Methodological advances now make it possible to test the extent to which genetic predisposition is common to the 2 conditions based on molecular genetic data.3 We sought to do so using publically available genome-wide association study (GWAS) summary statistics from large meta-analyses of schizophrenia4 and epilepsy.5 In this retrospective case-control analysis, we used a technique called linkage disequilibrium (LD) score regression (known as LDSC regression) to estimate the genetic correlation (rG) between these common disorders.3

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