We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Observation |

Non–N-Methyl-D-Aspartate Receptor Antibody Encephalitis With Cerebellitis With Associated Ovarian Teratoma

Andrew D. Smith III, MD1; Lawrence Samkoff, MD1
[+] Author Affiliations
1Department of Neurology, University of Rochester Medical Center, Rochester, New York
JAMA Neurol. 2015;72(11):1375-1377. doi:10.1001/jamaneurol.2015.1531.
Text Size: A A A
Published online


This case report describes a woman in her mid-20s who presented with fever, headache, encephalopathy, and ataxia.

The incidence of autoimmune and paraneoplastic encephalitis is increasing with improved recognition of clinical syndromes and diagnostic testing. Anti–N-methyl-D-aspartate receptor (NMDAR) encephalitis has been well described in young women with ovarian teratoma.1 The classic presentation of this syndrome is a subacute encephalopathy with mood disturbances, including psychosis, with variability of seizures and movement disorders. However, to our knowledge, there have been no reported associations between ovarian teratomas and paraneoplastic cerebellitis. Typically, paraneoplastic cerebellar degeneration or cerebellitis has been linked to anti-Yo antibody. More recently, cases of autoimmune and paraneoplastic cerebellitis have been reported with associated anti–Homer-3 and anti–metabotropic glutamate receptor 1 antibodies. Metabotropic glutamate receptor 1 has been associated with Hodgkin lymphoma, but there have been no reported neoplasms in cases of cerebellitis with positive Homer-3 antibodies.2,3

Figures in this Article

First Page Preview

View Large
First page PDF preview


Place holder to copy figure label and caption
Computed Tomography of the Abdomen and Pelvis

Coronal view of the abdomen and pelvis showing a right adnexal fat-containing mass with a soft tissue nodule in the wall (arrowhead).

Graphic Jump Location




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles