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Research Letter |

Association Between Glutamate Blockade and Fatigue in Patients With Multiple Sclerosis

Bardia Nourbakhsh, MD1; Nisha Revirajan, MD1; Emmanuelle Waubant, MD, PhD1
[+] Author Affiliations
1Department of Neurology, University of California–San Francisco
JAMA Neurol. 2015;72(11):1374-1375. doi:10.1001/jamaneurol.2015.2332.
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This analysis of a randomized, double-blind, placebo-controlled trial reports the effects of riluzole, a medication with glutamate-blocking properties, on fatigue in patients with early multiple sclerosis.

Excitotoxity, primarily mediated by excessive glutamate release, is one of the main proposed mechanisms for neurodegeneration in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis.1 However, a few clinical trials of medications with glutamate-blocking properties have not yet shown beneficial effects in patients with MS.

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Predicted Values of Modified Fatigue Impact Scale (MFIS) Score vs Visit Months in Placebo and Riluzole Groups Using the Mixed-Effects Regression Model
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