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Idiopathic Inflammatory Myopathy Treated With High-Dose Immunoablative Cyclophosphamide—A Long-term Follow-up Study

Arash H. Lahouti, MD1; Robert A. Brodsky, MD2; Lisa Christopher-Stine, MD, MPH1
[+] Author Affiliations
1Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland
2Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
JAMA Neurol. 2015;72(10):1205-1206. doi:10.1001/jamaneurol.2015.1425.
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This long-term case report describes a woman with idiopathic inflammatory myopathy treated with high-dose immunoablative cyclophosphamide.

To our knowledge, this is the first report of the use of high-dose immunoablative cyclophosphamide (HiCy) therapy in the absence of stem cell rescue in patients with idiopathic inflammatory myopathy.

Article InformationCorresponding Author: Lisa Christopher-Stine, MD, MPH, Division of Rheumatology, Johns Hopkins University School of Medicine, 5200 Eastern Ave, MFL Center Tower, Ste 4500, Baltimore, MD 21224 (lchrist4@jhmi.edu).

Conflict of Interest Disclosures: Dr Christopher-Stine reports serving on the advisory board; receiving honoraria from Novartis, Mallinckrodt, Walgreens, and Medimmune; and having membership in the advisory board of Idera. She has intellectual property rights in connection with Inova Diagnostics. No other disclosures were reported.

Funding/Support: This study was supported by the Huayi and Siuling Zhang Discovery Fund.

Role of the Funder/Sponsor: The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

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Figure.
T2 Short Tau Inversion Recovery Magnetic Resonance Image of the Thigh Muscles

A, Eight months before high-dose immunoablative cyclophosphamide (HiCy) therapy, significant muscle edema in posterior and lateral compartments of both thighs is evident. B, Twenty-one months after HiCy therapy, the muscles of the posterior and medial compartments have been largely replaced by adipose tissue/fibrosis, but there is no evidence of acute inflammation.

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