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Comment & Response |

Targeted Temperature Management for Cardiac Arrest—Reply

Niklas Nielsen, MD, PhD1,2; Matt P. Wise, MD, DPhil3; Tobias Cronberg, MD, PhD2,4
[+] Author Affiliations
1Department of Anesthesiology and Intensive Care, Helsingborg Hospital, Helsingborg, Sweden
2Department of Clinical Sciences, Lund University, Lund, Sweden
3Adult Critical Care, Cardiff University Hospital, Cardiff, United Kingdom
4Department of Neurology and Rehabilitation Medicine, Skane University Hospital, Lund, Sweden
JAMA Neurol. 2015;72(9):1076-1077. doi:10.1001/jamaneurol.2015.1380.
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In Reply We thank Deal et al for their interest in our article1 on cognitive function in the target temperature management after out-of-hospital cardiac arrest trial. The authors suggest that the time to initiation of targeted temperature management (TTM) and the time to achieving target temperature (TT) in our trial may have blunted any neuroprotective effect of a lower TT. They reference an observational single-center study by Sendelbach et al2 indicating higher odds of poor functional outcome when the time to TTM and the time to TT were increased.


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September 1, 2015
Nathan S. Deal, MD; Robert B. Schock, PhD; W. Frank Peacock, MD
1Section of Emergency Medicine, Baylor College of Medicine, Houston, Texas
2Research and Development, Life Recovery Systems, Kinnelon, New Jersey
JAMA Neurol. 2015;72(9):1076. doi:10.1001/jamaneurol.2015.1372.
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