Accepted for Publication: May 18, 2015.
Published Online: July 13, 2015. doi:10.1001/jamaneurol.2015.1359.
Study concept and design: Gregg, Lopez, Aizenstein, Price, Klunk.
Acquisition, analysis, or interpretation of data: Gregg, Kim, Gurol, Aizenstein, Price, Mathis, James, Snitz, Cohen, Kamboh, Minhas, Weissfeld, Tamburo, Klunk.
Drafting of the manuscript: Gregg, Kim, Klunk.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Gregg, Kim, Price, Weissfeld, Klunk.
Obtained funding: Lopez, Kamboh.
Administrative, technical, or material support: James, Minhas, Tamburo, Klunk.
Study supervision: Lopez, Klunk.
Conflict of Interest Disclosures: Dr Lopez served as a consultant for Baxter, Eli Lilly and Company, and Grifols. Drs Mathis and Klunk report that GE Healthcare holds a license agreement with the University of Pittsburgh based on the Pittsburgh compound B (PiB) positron emission tomography technology described in this article. Drs Mathis and Klunk are coinventors of PiB and, as such, have a financial interest in this license agreement; GE Healthcare provided no grant support for this study and had no role in the design or interpretation of results or preparation of this manuscript. No other disclosures were reported.
Funding/Support: This study was supported in part by National Institutes of Health grants P50 AG005133 (Drs Lopez and Klunk), R37 AG025516 (Dr Klunk), P01 AG025204 (Dr Klunk), AG041718 (Dr Kamboh), AG030653 (Dr Kamboh), and T32NS048005 (Dr Gurol).
Role of the Funder/Sponsor: The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.