Accepted for Publication: March 27, 2015.
Published Online: June 22, 2015. doi:10.1001/jamaneurol.2015.0749.
Study concept and design: Ariño, Höftberger, Dalmau, Graus.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Ariño, Dalmau, Graus.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Ariño.
Obtained funding: Ariño, Martínez-Hernández, Dalmau, Graus.
Study supervision: Saiz, Dalmau, Graus.
Conflict of Interest Disclosures: Dr Dalmau has a research grant from Euroimmun and receives royalties from patents for the use of Ma2 and N-methyl-D-aspartate receptor as autoantibody tests. No other disclosures were reported.
Funding/Support: This work was supported by National Institutes of Health grants RO1NS077851 and RO1MH094741 (Dr Domingo); grants 11/01780 (Dr Domingo) and 12/00611 (Dr Graus) from the Fondo Investigaciones Sanitarias, Spain; and Fundació la Marató TV3 (Dr Domingo). Dr Ariño is supported by a postresidency grant from Hospital Clinic, Barcelona; Dr Armangue by a grant from Instituto Carlos III (CM14/00081); and Dr Martínez-Hernández by a grant from Instituto Carlos III (CD14/00155), Madrid, Spain.
Role of the Funder/Sponsor: The funding organizations had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We thank all physicians who have contributed by providing clinical information of their patients and all patients for their generous contribution to research. We also thank Ellen Gelpi, MD (Institut d’Investigació Biomèdica August Pi i Sunyer brain bank), for her advice in the evaluation of the glutamic acid decarboxylase expression of tumors and Mercedes Alba and Eva Caballero (laboratory technicians, Institut d’Investigació Biomèdica August Pi i Sunyer) for technical support. They did not receive compensation from a funding sponsor for their contributions.