Accepted for Publication: April 16, 2015.
Published Online: June 15, 2015. doi:10.1001/jamaneurol.2015.0979.
Study concept and design: Korvatska, Raskind, Bird.
Acquisition, analysis, or interpretation of data: Korvatska, Leverenz, Jayadev, McMillan, Kurtz, Guo, Rumbaugh, Matsushita, Girirajan, Dorschner, Kiianitsa, Yu, Brkanac, Garden, Bird.
Drafting of the manuscript: Korvatska, Jayadev, Kiianitsa, Raskind, Bird.
Critical revision of the manuscript for important intellectual content: Korvatska, Leverenz, Jayadev, McMillan, Kurtz, Guo, Rumbaugh, Matsushita, Girirajan, Dorschner, Yu, Brkanac, Garden, Raskind, Bird.
Statistical analysis: Jayadev, McMillan, Garden.
Obtained funding: Korvatska, Raskind, Bird.
Administrative, technical, or material support: Kurtz, Guo, Rumbaugh, Matsushita, Girirajan, Dorschner, Kiianitsa, Yu, Brkanac, Bird.
Study supervision: Korvatska, Leverenz, Jayadev, Garden, Raskind, Bird.
Conflict of Interest Disclosures: Dr Leverenz has received compensation for consultation for Navidea Biopharmaceuticals, Piramal Healthcare, and Sanofi. He has received grant funding from Genzyme and Sanofi. No other disclosures were reported.
Funding/Support: This research was supported by grants from the Department of Veterans Affairs (Geriatric Research, Education, and Clinical Centers); National Institutes of Health grants ADRC P50 AG005136, R01 AG041797-01 (National Institute on Aging Genetics Initiative for Late-Onset Alzheimer’s Disease), R01 NS069719, R01 AG039700, and RC1 AG035681; the Van Beber Alzheimer’s Disease Research Fund; and Washington State Life Sciences Discovery Funds grant 2065508 to the University of Washington Northwest Institute of Genetic Medicine.
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We are grateful to the many members of our families with late-onset Alzheimer disease who have contributed time and samples to this research project and to the National Institutes of Health/National Institute on Aging Genetics Initiative for Late-Onset Alzheimer’s Disease study. We thank Kim Howard, BS, University of Washington Neuropathology Core, Aimee Schantz, MEd, University of Washington Neuropathology Core, Lynn Greenup, BS, GRECC - VAPSHCS, and Julio Vazquez, PhD, Fred Hutchinson Cancer Center, for excellent technical support; and Jessica Hamerman, PhD, Beyaroya Research Institute, for critical reading of the manuscript. These persons were not compensated by a funding sponsor. Ellen Steinbart, RN, University of Washington, provided close liaison with the LOAD123 family and was compensated by National Institutes of Health grant ADRC P50 AG005136.