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A New Association Between Castleman Disease and Immune-Mediated Cerebellitis FREE

Sarah Lee, MD1; Scheherazade Le, MD1
[+] Author Affiliations
1Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California
JAMA Neurol. 2015;72(6):722-723. doi:10.1001/jamaneurol.2015.0091.
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Published online

REPORT OF A CASE

A previously healthy man in his 30s awoke one morning with acute, extreme vertigo; unsteady gait; and dyscoordination. His symptoms progressed despite treatment with diazepam and meclizine, and he presented to our hospital 1 month after symptom onset unable to walk or feed himself. Neurologic examination was significant for oscillopsia, nystagmus in all directions of gaze, scanning speech, and profound truncal and appendicular ataxia. He could neither stand nor ambulate owing to imbalance.

Institutional review board approval was not obtained because it is not required for case reports at our institution; the patient provided oral consent.

Brain magnetic resonance imaging revealed leptomeningeal enhancement between the cerebellar folia (Figure 1A). Cerebrospinal fluid tests revealed white blood cell count of 16/µL (96% lymphocytes) (to convert white blood cell count to ×109 per liter, multiply by 0.001), red blood cell count of less than 1 ×106/µL (to convert to ×1012 per liter, multiply by 1.0), and normal protein and glucose levels; viral, fungal, and bacterial culture results were negative (including varicella-zoster virus, herpes simplex virus types 1 and 2, enterovirus, Lyme, and cryptococcus); and oligoclonal bands, cytology, and flow cytometry were unremarkable. Cerebrospinal fluid test results were negative for autoantibodies to antineuronal nuclear antibody 1 (anti-Hu), antineuronal nuclear antibody 2 (anti-Ri), antineuronal nuclear antibody 3, antiglial nuclear antibody 1, Purkinje cell cytoplasmic antibody type 1 (anti-Yo), Purkinje cell cytoplasmic antibody type 2, amphiphysin, and collapsin response mediator protein 5 (anti-CV2). Serum paraneoplastic panel results were negative, which included the same cerebrospinal fluid antibodies plus anti-Ma1, anti-Zic4, anti-GAD65, Purkinje cell cytoplasmic antibody type Tr, P/Q- and N-type calcium channel antibodies, voltage-gated potassium channel, N-methyl-D-aspartate receptor, and acetylcholine receptor antibodies. Serum studies revealed only an isolated elevated interleukin 6 level at 26 pg/mL (normal, <5 pg/mL). Results from human immunodeficiency virus RNA polymerase chain reaction and human herpesvirus 8 IgG and DNA testing were negative. Computed tomographic scans of the chest, abdomen, and pelvis found multiple anterior mediastinal soft-tissue nodules that were metabolically active on positron emission tomography with fluorodeoxyglucose. Thymic and lymph node biopsies confirmed the diagnosis of hyaline vascular Castleman disease (Figure 2).

Place holder to copy figure label and caption
Figure 1.
Brain Magnetic Resonance Imaging at Presentation and 3 Weeks Later

A, Magnetic resonance image at presentation shows axial T1 postcontrast sequence demonstrating abnormal enhancement in the bilateral cerebellar folia. B, Magnetic resonance image 3 weeks after presentation shows sagittal T2 image demonstrating subtle cerebellar atrophy. The previously seen enhancement is resolved.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.
Histopathological Slide With Castleman Follicle

Atretic germinal center surrounded by concentric rings of lymphocytes with “onion-skinning” appearance (hematoxylin-eosin; original magnification ×100).

Graphic Jump Location

The patient underwent treatment with intravenous immunoglobulin for 5 days (0.4 g/kg/d), followed by 1 g intravenous solumedrol daily for 5 days along with intensive physical, occupational, and speech therapy but failed to improve clinically. The mediastinal mass was resected on hospital day 16, and repeated magnetic resonance imaging 3 weeks after presentation (6 days postresection) showed resolution of cerebellar enhancement and subtle cerebellar degeneration (Figure 1B). He was discharged to a rehabilitation facility and, at 6-month follow-up, remained wheelchair dependent with persistent ataxia and diplopia. He was lost to follow-up before more aggressive treatment could be instituted.

DISCUSSION

The cerebellum is a frequent immunologic target, perhaps because its Purkinje cells possess multiple optimal antigens. The most commonly described cerebellar syndromes are paraneoplastic, but many others have been described in the setting of non-neoplastic disease such as gluten ataxia, anti-GAD antibodies, or postinfectious cerebellitis.1 Immune-mediated ataxias tend to affect the cerebellar vermis first: imbalance, speech, and vision changes are common initial presentations. An early magnetic resonance image may show meningeal enhancement; atrophy is seen on later scans.2,3 Paraneoplastic cerebellar degeneration generally carries a poor prognosis but immune-mediated cerebellar syndromes can have variable outcomes.1,3 Our patient was lost to follow-up before maintenance immunotherapy could be instituted or more aggressive immunomodulatory therapies could be trialed, which may have improved his long-term outcome.

Castleman disease is a lymphoproliferative disorder subcategorized by morphology (unicentric vs multicentric) and histopathology (hyaline vascular, plasma cell, or human herpesvirus 8–associated variants). Although Castleman disease is by definition non-neoplastic, its more aggressive plasma cell and human herpesvirus 8–associated forms have been described with other paraneoplastic disorders such as POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes) syndrome and Kaposi sarcoma, as well as with hematologic malignancies such as Hodgkin and non-Hodgkin lymphoma, which in turn have been associated with cerebellar syndromes.3,4 Our patient had the more common hyaline vascular form (representing approximately 90% of Castleman disease cases); this subtype has rare autoimmune or paraneoplastic associations.

A specific autoantibody in this case was not identified. Neither anti-mGluR1 nor CASPR2 antibodies were tested; both have been found in cases of unexplained cerebellar ataxia.5,6 However, the rarity of both Castleman disease and immune-mediated cerebellitis strongly suggest a new association not previously described.

ARTICLE INFORMATION

Corresponding Author: Sarah Lee, MD, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, 300 Pasteur Dr, A343, Stanford, CA 94305 (slee10@stanford.edu).

Conflict of Interest Disclosures: None reported.

REFERENCES

Hadjivassiliou  M.  Immune-mediated acquired ataxias. Handb Clin Neurol. 2012;103:189-199.
PubMed
Rosenfeld  MR, Dalmau  J.  Central nervous system paraneoplastic disease. Handb Clin Neurol. 2012;105:853-864.
PubMed
Vernino  S.  Paraneoplastic cerebellar degeneration. Handb Clin Neurol. 2012;103:215-223.
PubMed
Bonekamp  D, Horton  KM, Hruban  RH, Fishman  EK.  Castleman disease: the great mimic . Radiographics2011;31(6):1793-1807.
PubMed   |  Link to Article
Iorio  R, Damato  V, Mirabella  M,  et al.  Cerebellar degeneration associated with mGluR1 autoantibodies as a paraneoplastic manifestation of prostate adenocarcinoma. J Neuroimmunol. 2013;263(1-2):155-158.
PubMed   |  Link to Article
Becker  EB, Zuliani  L, Pettingill  R,  et al.  Contactin-associated protein-2 antibodies in non-paraneoplastic cerebellar ataxia. J Neurol Neurosurg Psychiatry. 2012;83(4):437-440.
PubMed   |  Link to Article

Figures

Place holder to copy figure label and caption
Figure 1.
Brain Magnetic Resonance Imaging at Presentation and 3 Weeks Later

A, Magnetic resonance image at presentation shows axial T1 postcontrast sequence demonstrating abnormal enhancement in the bilateral cerebellar folia. B, Magnetic resonance image 3 weeks after presentation shows sagittal T2 image demonstrating subtle cerebellar atrophy. The previously seen enhancement is resolved.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.
Histopathological Slide With Castleman Follicle

Atretic germinal center surrounded by concentric rings of lymphocytes with “onion-skinning” appearance (hematoxylin-eosin; original magnification ×100).

Graphic Jump Location

Tables

References

Hadjivassiliou  M.  Immune-mediated acquired ataxias. Handb Clin Neurol. 2012;103:189-199.
PubMed
Rosenfeld  MR, Dalmau  J.  Central nervous system paraneoplastic disease. Handb Clin Neurol. 2012;105:853-864.
PubMed
Vernino  S.  Paraneoplastic cerebellar degeneration. Handb Clin Neurol. 2012;103:215-223.
PubMed
Bonekamp  D, Horton  KM, Hruban  RH, Fishman  EK.  Castleman disease: the great mimic . Radiographics2011;31(6):1793-1807.
PubMed   |  Link to Article
Iorio  R, Damato  V, Mirabella  M,  et al.  Cerebellar degeneration associated with mGluR1 autoantibodies as a paraneoplastic manifestation of prostate adenocarcinoma. J Neuroimmunol. 2013;263(1-2):155-158.
PubMed   |  Link to Article
Becker  EB, Zuliani  L, Pettingill  R,  et al.  Contactin-associated protein-2 antibodies in non-paraneoplastic cerebellar ataxia. J Neurol Neurosurg Psychiatry. 2012;83(4):437-440.
PubMed   |  Link to Article

Correspondence

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