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Comment & Response |

Diagnosing Encephalitis, Not Otherwise Specified

Yingjie Zou, MD1; Harrison Xiao Bai, MD2; Yongguang Tao, PhD1
[+] Author Affiliations
1Cancer Research Institute of Xiangya School of Medicine, Central South University, Changsha, Hunan, People’s Republic of China
2Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia
JAMA Neurol. 2015;72(6):725-726. doi:10.1001/jamaneurol.2015.0545.
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To the Editor We read with interest an article published by Gelfand et al1 on a series of 49 patients with encephalitis, not otherwise specified (ENOS) diagnosed by brain biopsy. The authors suggested that ENOS was the most common initial histopathologic diagnosis among all types of encephalitis and standard histologic evaluation is unlikely to yield specific causes unless additional analyses are performed. We believe that such a conclusion is unwarranted because the authors did not report either the indication for biopsy or the prebiopsy diagnosis of the patients included in the study.

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June 1, 2015
Zhi-li Wang, MD; Eric Lancaster, MD, PhD; Li Yang, MD, PhD
1Department of Neurology, The Second Xiangya Hospital, Central South University, Hunan, China
2Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia
JAMA Neurol. 2015;72(6):725. doi:10.1001/jamaneurol.2015.0542.
June 1, 2015
Jeffrey M. Gelfand, MD, MAS; Tarik Tihan, MD, PhD; Bruce A. Cree, MD, PhD, MAS
1Department of Neurology, University of California, San Francisco
1Department of Neurology, University of California, San Francisco2Multiple Sclerosis Center, University of California, San Francisco
JAMA Neurol. 2015;72(6):726-727. doi:10.1001/jamaneurol.2015.0548.
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