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Comment & Response |

Diagnosing Encephalitis, Not Otherwise Specified

Zhi-li Wang, MD1; Eric Lancaster, MD, PhD2; Li Yang, MD, PhD1
[+] Author Affiliations
1Department of Neurology, The Second Xiangya Hospital, Central South University, Hunan, China
2Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia
JAMA Neurol. 2015;72(6):725. doi:10.1001/jamaneurol.2015.0542.
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To the Editor We read with interest an article published by Gelfand et al.1 The authors presented their institutional series of 49 patients who were given the initial diagnosis of encephalitis, not otherwise specified (ENOS) on pathologic review. For the 29 patients whose original pathologic material was available for review, subsequent neuropathologic review led to a more specific categorization in 34%. Among the 19 patients who still had ENOS after additional neuropathologic review, a definite diagnosis was reached in 32% based on ancillary testing, subsequent clinical information, and clinical follow-up. The authors concluded that it may be worthwhile to have the biopsy materials reviewed again because an original diagnosis of ENOS could be classified into a more specific disease category in a third of the cases.

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June 1, 2015
Yingjie Zou, MD; Harrison Xiao Bai, MD; Yongguang Tao, PhD
1Cancer Research Institute of Xiangya School of Medicine, Central South University, Changsha, Hunan, People’s Republic of China
2Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia
JAMA Neurol. 2015;72(6):725-726. doi:10.1001/jamaneurol.2015.0545.
June 1, 2015
Jeffrey M. Gelfand, MD, MAS; Tarik Tihan, MD, PhD; Bruce A. Cree, MD, PhD, MAS
1Department of Neurology, University of California, San Francisco
1Department of Neurology, University of California, San Francisco2Multiple Sclerosis Center, University of California, San Francisco
JAMA Neurol. 2015;72(6):726-727. doi:10.1001/jamaneurol.2015.0548.
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