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Viewpoint |

The Future of Research in Multiple Sclerosis

Robert J. Fox, MD1; Richard A. Rudick, MD2
[+] Author Affiliations
1Mellen Center for Multiple Sclerosis, Neurological Institute, Cleveland Clinic, Cleveland, Ohio
2Biogen, Boston, Massachusetts
JAMA Neurol. 2015;72(8):853-854. doi:10.1001/jamaneurol.2015.0270.
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This Viewpoint discusses new areas of focus in multiple sclerosis, including progressive multiple sclerosis, contributors to multiple sclerosis, and learning from the real world.

Over the past 2 decades, advances in immunology, imaging, and experimental therapeutics have led to dramatic progress in understanding and treating multiple sclerosis (MS). Currently, there are more than 12 US Food and Drug Administration–approved therapies for MS, with more in development. Magnetic resonance imaging has been shown to be useful both in screening novel anti-inflammatory therapies in phase 2 trials and in identifying patients with suboptimal treatment response in clinical practice. Pharmacologic and other treatment approaches have demonstrated effectiveness in alleviating symptoms and compensating for disability. Despite these advances, there remain many critical needs in understanding and treating MS.

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