Accepted for Publication: April 10, 2015.
Published Online: June 8, 2015. doi:10.1001/jamaneurol.2015.0941.
Study concept and design: Zanotti-Fregonara, Kreisl, Innis, Theodore.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Gershen, Zanotti-Fregonara, Hirvonen, Theodore.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Gershen, Hirvonen, Hong, Theodore.
Obtained funding: Innis, Theodore.
Administrative, technical, or material support: Dustin, Kreisl, Brouwer, Zoghbi, Innis, Theodore.
Study supervision: Zanotti-Fregonara, Hirvonen, Pike, Innis, Theodore.
Conflict of Interest Disclosures: None reported.
Funding/Support: This work was supported by the Intramural Research Programs of the National Institute of Mental Health and National Institute of Neurological Disorders and Stroke, National Institutes of Health.
Role of the Funder/Sponsor: All authors except Ms Gershen were employees of the National Institutes of Health when this research was performed, and they directed the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, and approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: Desiree Ferraris Araneta, CRNP, and Denise Rallis-Frutos, DNP, APRN/PMH, MsED, MSN, National Institutes of Health, Bethesda, Maryland, provided clinical coverage for positron emission tomographic scanning. Ioline Henter, MA, National Institutes of Health, provided editorial support. Daniel Goldenholz, MD, PhD, National Institutes of Health, participated in clinical patient evaluation. Alicia Woock, BA, National Institutes of Health, assisted in radiometabolite analysis. All performed the work as part of their official US government duties and received no compensation for their efforts.
Correction: This article was corrected on June 11, 2015, to fix an error in the byline.