Accepted for Publication: April 6, 2015.
Published Online: June 8, 2015. doi:10.1001/jamaneurol.2015.0853.
Study concept and design: Selcen, Shen, Ohno, Engel.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Selcen, Ohno, Engel.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Shen, Engel.
Obtained funding: Selcen, Ohkawara, Ohno, Engel.
Administrative, technical, or material support: Ohno, Engel.
Study supervision: Ohno, Engel.
Conflict of Interest Disclosures: None reported.
Funding/Support: This work was supported by National Institutes of Health grant NS62777 (Dr Engel), the Mayo Clinic Center for Individualized Medicine, and by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology and Ministry of Health, Labour and Welfare of Japan (Drs Ohkawara and Ohno).
Role of Funder/Sponsor: The funding sources had no role in the design and conduct of the study; collection, management, analysis, or interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.