Accepted for Publication: March 19, 2015.
Published Online: May 18, 2015. doi:10.1001/jamaneurol.2015.0606.
Study concept and design: All authors.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Chung, Babulal, Cairns, Roe, Morris.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Babulal, Monsell, Roe.
Administrative, technical, or material support: Cairns.
Study supervision: Monsell, Cairns, Roe.
Conflict of Interest Disclosures: Dr Morris has participated or is currently participating in clinical trials of antidementia drugs sponsored by the following companies and studies: Janssen Immunotherapy, Pfizer, Eli Lilly/Avid Radiopharmaceuticals, the SNIFF (Study of Nasal Insulin to Fight Forgetfulness) study, and the A4 (Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Disease) trial. Dr Morris has served as a consultant for Lilly USA, ISIS Pharmaceuticals, and the Charles Dana Foundation. He receives research support from Eli Lilly/Avid Radiopharmaceuticals and is funded by National Institutes of Health grants P50AG005681, P01AG003991, P01AG026276, and U19AG032438.
Funding/Support: Funding for this study was provided by the NIA (grants P50-AG05681, P01-AG03991, and P01-AG026276 to Dr Morris), Fred Simmons, Olga Mohan, and the Charles F. and Joanne Knight Alzheimer’s Research Initiative of the Washington University Charles F. and Joanne Knight Alzheimer’s Disease Research Center. A portion of Dr Roe’s salary was supported by grant R01-AG15928.
Role of the Funder/Sponsor: The funders/sponsors had no role in the design and conduct of the study; collection, management, analysis, or interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Information: The NACC database is funded by NIA/National Institutes of Health grant U01 AG016976. The NACC data were obtained from the NIA-funded AD centers (grants P30 AG019610 [PI Eric Reiman, MD], P30 AG013846 [PI Neil Kowall, MD], P50 AG008702 [PI Scott Small, MD], P50 AG025688 [PI Allan Levey, MD, PhD], P30 AG010133 [PI Andrew Saykin, PsyD], P50 AG005146 [PI Marilyn Albert, PhD], P50 AG005134 [PI Bradley Hyman, MD, PhD], P50 AG016574 [PI Ronald Petersen, MD, PhD], P50 AG005138 [PI Mary Sano, PhD], P30 AG008051 [PI Steven Ferris, PhD], P30 AG013854 [PI M. Marsel Mesulam, MD], P30 AG008017 [PI Jeffrey Kaye, MD], P30 AG010161 [PI David Bennett, MD], P30 AG010129 [PI Charles DeCarli, MD], P50 AG016573 [PI Frank LaFerla, PhD], P50 AG016570 [PI Dale Bredesen, PhD], P50 AG005131 [PI Douglas Galasko, MD], P50 AG023501 [PI Bruce Miller, MD], P30 AG035982 [PI Russell Swerdlow, MD], P30 AG028383 [PI Linda Van Eldik, PhD], P30 AG010124 [PI John Trojanowski, MD, PhD], P50 AG005133 [PI Oscar Lopez, MD], P50 AG005142 [PI Helena Chui, MD], P30 AG012300 [PI Roger Rosenberg, MD], P50 AG005136 [PI Thomas Montine, MD, PhD], P50 AG033514 [PI Sanjay Asthana, MD, FRCP], and P50 AG005681 [PI Dr Morris]).