Accepted for Publication: March 17, 2015.
Published Online: May 11, 2015. doi:10.1001/jamaneurol.2015.0582.
Study concept and design: Kooperberg, Peters, Rich.
Acquisition, analysis, or interpretation of data: Auer, Nalls, Meschia, Worrall, Longstreth, Seshadri, Burger, Carlson, Carty, Chen, Cupples, DeStefano, Fornage, Hardy, Hsu, Jackson Jarvik, Kim, Lakshminarayan, Lange, Manichaikul, Quinlan, Singleton, Thornton, Nickerson, Rich.
Drafting of the manuscript: Rich.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Auer, Nalls, Kooperberg.
Obtained funding: Jackson, Nickerson, Rich.
Administrative, technical, or material support: Kooperberg, Nickerson, Peters Rich.
Study supervision: Nickerson, Peters, Rich.
Conflict of Interest Disclosures: None reported.
Funding/Support: Funding for GO ESP was provided by NHLBI grants RC2 HL-103010 (HeartGO), RC2 HL-102923 (LungGO), and RC2 HL-102924 (Women’s Health Initiative Sequencing Project). The exome sequencing was performed through NHLBI grants RC2 HL-102925 (BroadGO) and RC2 HL-102926 (SeattleGO). HeartGO components and their support include Atherosclerosis Risk in Communities (NHLBI contracts N01 HC-55015, N01 HC-55016, N01HC-55017, N01 HC-55018, N01 HC-55019, N01 HC-55020, and N01 HC-55021); Cardiovascular Health Study (NHLBI contracts HHSN268201200036C, HHSN268200800007C, N01HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, and N01HC85086); and NHLBI grants U01HL080295, R01HL087652, R01HL105756, R01HL103612, and R01HL120393, with additional contribution from the National Institute of Neurological Disorders and Stroke. Additional support was provided through R01AG023629 from the National Institute on Aging. A full list of principal Cardiovascular Health Study investigators and institutions can be found at CHS-NHLBI.org; Coronary Artery Risk Development in Young Adults (NHLBI contracts N01-HC95095, N01-HC48047, N01-HC48048, N01-HC48049, and N01-HC48050); Framingham Heart Study ( NHLBI contract N01-HC-25195 and grants NS17950, AG08122, and AG033193); Jackson Heart Study (NHLBI contracts N01 HC-95170, N01 HC-95171, and N01 HC-95172); Multi-Ethnic Study of Atherosclerosis (NHLBI contracts N01-HC-95159 through N01-HC-95169 and grant 024156). The Siblings with Ischemic Stroke Study (grant R01-NS39987) and the Ischemic Stroke Genetics Study (grant R01-NS42733) contributed phenotypic data and DNA samples. Dr Nalls’ participation in this research was supported, in part, by the Intramural Research Program of the National Institute on Aging (grant Z01-AG000954-7). Portions of this study used the high-performance computational capabilities of the Biowulf Linux cluster at the National Institutes of Health (NIH) (http://biowulf.nih.gov). The Women’s Health Initiative program is funded by the NHLBI through contracts HHSN268201100046C, HHSN268201100001C, HHSN268201100002C, HHSN268201100003C, HHSN268201100004C, and HHSN271201100004C, and grant RC2-HL102924 for the Women’s Health Initiative Sequencing Project. LungGO components and their support include Cystic Fibrosis Foundation (Cystic Fibrosis Foundation grants GIBSON07K0, KNOWLE00A0, OBSERV04K0, and RDP R026), and NIH (grants R01-HL068890, R02-HL095396, UL1-RR025014, and 5R00-HG004316); Chronic Obstructive Pulmonary Disease (COPDGene; NIH grants U01-HL089897 and U01-HL089856), and the COPD Foundation through contributions made to an industry advisory board comprising AstraZeneca, Boehringer Ingelheim, Novartis, Pfizer, and Sunovian; Acute Lung Injury (NIH grant RC2-HL101779); Lung Health Study (NIH grants RC2-HL066583, R01-HG004738, and HR-46002); Pulmonary Arterial Hypertension (NIH grants P50-HL084946, K23-AR52742, and F32-HL083714); and Asthma (NIH grants RC2-HL101651, HL077916, HL-69197, HL-76285, and M01-RR07122).
Role of the Funder/Sponsor: The funding organization (NIH/NHLBI) had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Group Information: NHLBI Exome Sequencing Project members are listed in eAppendix 1 in the Supplement.
Additional Contributions: The support of the research institutions, study investigators, field staff, and study participants assisted in creating this resource for biomedical research.